Inert-Atmosphere Workstation to Enable New Advances in Catalytic Borylation and Cross-Coupling Reactions

随着药物、杀虫剂、聚合物和食品添加剂等发现的出现，有机化学是一门强大的科学，在过去的一个世纪里帮助我们的现代社会享受到了预期寿命和生活水平的显著提高。新药物和商品化学品的发现依赖于新反应、新试剂和新催化剂的持续投入(催化剂是一种物种，少量使用，能够促进和/或加速化学反应)。这份RTI拨款申请描述了一项为我的实验室购买一个基本的、紧凑的、惰性气氛的手套箱和一个冰箱单元的建议。在有机金属化学中，为了开发和优化使用对水和空气敏感的催化剂、配体和反应物的新反应过程，随时可以接触到手套箱是至关重要的。我们对手套箱的迫切需求以我的实验室正在进行的三个项目为例，这些项目涉及开发创新的过渡金属催化的硼化反应，以提供新的有效方法来制备具有重要药用价值的中间体，如多取代哌啶和手性硼酸盐。其中两个项目目前因缺乏手套箱而被推迟，它们是P.I.的核心项目。S最近批准了探索基金的申请，这些项目的成功有赖于随之而来的手套箱的RTI申请。这一工具将极大地改善P.I.S研究小组中至少4-5名同事的培训环境，他们将发展重要的技术技能，这些技能对制药和化工行业的就业非常重要。

With discoveries like drugs, insecticides, polymers, and food additives, organic chemistry is a powerful science that has helped our modern society enjoy a dramatic increase in life expectancy and standard of living in the past century. The discovery of new drugs and commodity chemicals rely on a continuous input of new reactions, new reagents, and new catalysts (catalysts are species, used in a small amount, that enable and/or accelerate chemical reactions). This RTI grant application describes a proposal to acquire a basic, compact, inert-atmosphere glove box with a refrigerator unit for my laboratory. In organometallic chemistry, ready access to a glove box is crucial in order to develop and optimize new reaction processes using water- and air-sensitive catalysts, ligands, and reactants. Our urgent need for a glove box is acutely exemplified with three ongoing projects in my laboratory involving the development of innovative transition metal-catalyzed borylation reactions to provide new and effective ways to prepare pharmaceutically important intermediates such as polysubstituted piperidines and chiral boronates. Two of these projects, which are currently delayed for lack of a glove box, were at the heart of the P.I.'s recently approved Discovery Grant application and the success of these projects relies on this attendant RTI application for a glove box. This instrument will greatly enhance the training environment of at least 4-5 co-workers in the P.I.'s research group who will develop important technical skills of great importance for employment in the pharmaceutical and chemical industry.