Novel Delivery System for High Dose Rate Intensity Modulated Brachytherapy with Yb-169 as a Radiation Source

放射治疗是一种有效和安全的癌症治疗方法。大约50%的癌症患者 ** 受益于这种治疗，也就是说，每年有近10万加拿大人患有癌症。近距离放射治疗是一种放射疗法，其中放射源被放置在肿瘤内部或 ** 附近，使用短时间内植入的细空心管（导管），** 对肿瘤给予高辐射剂量，同时对周围健康组织保持低剂量。然而，传统近距离放射治疗中的剂量分布在所有方向上都是相同的，导致剂量溢出到辐射敏感的健康组织。该建议旨在开发一种新型辐射输送系统，该系统将通过在植入的中空管内结合辐射屏蔽来 ** 操纵辐射剂量以符合肿瘤的形状，即输送系统将调制从近距离放射治疗源发射的辐射的强度 **。防护罩可以在治疗过程中旋转，将辐射导向肿瘤，远离健康组织。发展和使强度 ** 调制近距离放射治疗在临床上可用，将显着提高 ** 近距离放射治疗的潜力，降低毒性，将提高治愈率，改善加拿大人前列腺癌，乳腺癌，宫颈癌，子宫癌，阴道癌，外阴癌，头颈癌和 ** 食管癌的生活质量。此外，该提案将为本科生和研究生提供在放射肿瘤学、放射物理学、生物学、计算和工程学等多学科环境中工作的机会。

Radiotherapy is an effective and safe treatment for cancer. Approximately 50% of cancer**patients benefit from this treatment, that is, close to 100,000 Canadians with cancer each**year. Brachytherapy, is a form of radiotherapy where radioactive sources are placed inside or**near the tumours using thin, hollow tubes (catheters) implanted for a short period of time,**giving a high radiation dose to the tumour while maintaining a low dose to surrounding healthy tissues. However, dose distribution in conventional brachytherapy is identical in all directions resulting in dose spillage to radiation sensitive**healthy tissues. This proposal aims to develop a novel radiation delivery system that will**manipulate the radiation dose to conform to the shape of a tumour by incorporating radiation**shields inside the implanted hollow tubes, i.e. the delivery system will modulate the intensity**of the emitted radiation from the brachytherapy source. The shields can rotate during the**treatment, direct the radiation towards the tumour and away from healthy tissues. Developing and making intensity**modulated brachytherapy clinically available, will significantly improve the potential of**brachytherapy with reduced toxicity will increase the cure rates and improve the quality of life**for Canadians with prostate, breast, cervical, uterine, vaginal, vulvar, head & neck and**oesophageal cancers. In addition, this proposal will offer undergraduate and graduate student**to work in a multidisciplinary environment with radiation oncology, radiation physics, biology,**computing and engineering.