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Molecular evolution of self-nonself discrimination by paired NKR-P1 receptors, self ligands, and viral immunoevasins

Molecular evolution of self-nonself discrimination by paired NKR-P1 receptors, self ligands, and viral immunoevasins
成对 NKR-P1 受体、自身配体和病毒免疫逃避蛋白的自我-非自我歧视的分子进化
批准号：
382745
负责人：
Carlyle James R
金额：
$47.37万
依托单位：
Sunnybrook Research Institute (Toronto, Ontario)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2018
资助国家：
加拿大
项目状态：
已结题
起止时间：
2018-03-01 至 2023-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=382745&lang=en
关键词：
Co-Evolution Host-Pathogen Interactions Immunoevasin Innate Immunity Mouse Cytomegalovirus Natural Killer Cell Nkr-P1:Clr Self-Nonself Discrimination Viral Immune Evasion X-Ray Crystal Structure

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中文摘要
翻译
先天免疫系统保护我们免受致病细菌，病毒和癌症的侵害，并有助于维持粘膜屏障的正常组织功能，如皮肤，肠道和肺部。自然杀伤（NK）细胞是先天性淋巴样细胞（I
英文摘要
The innate immune system protects us from pathogenic bacteria, viruses, and cancer, and also helps to maintain normal tissue function at mucosal barriers, such as the skin, gut, and lungs. Natural killer (NK) cells are a subset of innate lymphoid cells (I
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Molecular mechanisms of natural killer (NK) and innate lymphoid cell (ILC) development and function in health and disease
NK cell receptor-ligand interactions in recognition of tumour cells and infected targets.
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