Assessment of Polyglyoxylates for Colon-Specific Drug Delivery Capsule Production

该项目将评估一种新型可触发聚合物用于制造**药物胶囊的潜力。近年来，药物在结肠中的选择性释放一直是人们越来越感兴趣的目标，因为它有可能改善局部疾病的治疗，如克罗恩病、肠易激病、溃疡性结肠炎、结肠癌，并满足与粪便移植技术相关的需求。然而，用药物靶向结肠是具有挑战性的，因为它位于胃肠道的末端，受到pH值变化、转运时间和液体体积等挑战的影响。结合起来，学术和公司项目团队已经开发出一种通过注射成型制造**药物胶囊的系统，这是一种通常应用于塑料加工的技术，以及一种**聚合物，有望在胃肠道的特定位置进行特定降解。拟议的项目将**涉及开发和优化聚合物在低温条件下的降解，同时获得**适合注塑加工的性能。

This project will assess the potential for a new class of triggerable polymers to be used in the manufacture of**pharmaceutical capsules. The selective release of drugs in the colon has been a target of increasing interest in**recent years due to its potential to improve the treatment of local diseases such as Crohns disease, irritable**bowel disease, ulcerative colitis, colon cancer, and to meet the needs associated with fecal transplant**technologies. However, targeting the colon with drugs is challenging as it is located at the end of the**gastrointestinal (GI) tract and is affected by challenges such as variability in pH, transit times, and fluid volumes.**Combined, the academic and company project teams have developed a system for the manufacture of**pharmaceutical capsules by injection molding, a technique commonly applied to the processing of plastics, and a**polymer that shows promise for specific degradation at defined locations in the GI tract. The proposed project will**involve the development and optimization of the polymer for degradation under colic conditions while achieving**suitable properties for processing by injection molding.