Investigating Toxicity of Airborne Metal Nanoparticles: Mechanisms and Characterization

纳米颗粒（NP，体外毒性测试系统，以更大的确定性筛选、排名和预测NP的毒性作用，和ii）使用毒理基因组学方法鉴定和表征因果因素和NP毒性。在接下来的五年里，我的短期目标将评估吸入金属纳米颗粒的毒性，并通过提供有关其因果因素和机制的更多信息，优先考虑在动物研究中更深入地使用纳米颗粒。我特别提议：1）阐明NP增强肺部细菌感染的根本原因和机制，2）评估肺部NP暴露对心血管系统的影响。**随着这项研究的成功完成，将有许多好处提供（1）HQP独特的培训机会，为一个新的分支的科学（2）关于NP毒性的等级和用于作为成本有效筛选的体内测试的NP的优先级的有价值的信息;（3）了解NP暴露产生生物反应的机制，因为这将使我们处于有利地位，以制定设计安全NP的策略。

Nanoparticle (NP, in vitro toxicity testing system to screen, rank and predict with greater certainty the toxic effects of NPs and ii) identify and characterize the causal factors and NP toxicity using a toxicogenomic approach. Over the next five years, my short-term objectives will assess the toxicity of inhaled metal NPs and prioritize NPs for more in depth in animal studies by providing more information on its causal factors and mechanisms. I specifically propose to: 1) elucidate the underlying causes and mechanisms by which NPs enhance lung bacterial infection and 2) assess the effects of pulmonary NP exposure on the cardiovascular system.******With successful completion of this research, there will be many benefits providing (1) HQP with unique training opportunities for a new branch of science (nanotoxicology); (2) valuable information on the rank of NP toxicity and prioritization of NPs for in vivo testing as a cost-effective screening; (3) understanding of the mechanisms by which NP exposures produce biological responses as this will put us in a strong position to develop strategies to design safe NPs.