Development and mechanisms of stress resiliency.

对压力源的行为和/或生理反应使生物体能够有效地应对挑战，并恢复体内平衡。虽然有必要，但压力反应会对某些人产生各种有害影响。然而，并不是所有暴露在压力下的个体都能观察到这样的影响，甚至是极端的创伤，所以，尽管揭示对压力影响的脆弱性的潜在机制很重要，但同样有效的是提出一个问题——“在面对压力时具有弹性的个体是什么机制在起作用？”面对不断变化的环境，一个可变的应对策略将是最有效的建立一个人的弹性，而不是脆弱，压力。我们将使用动物模型来研究应对和恢复的潜在机制。我们将以过去的工作为基础，调查早期和青少年环境（父母、社会结构）中关键因素对成年后建立应对行为的影响。我们还将研究潜在的神经机制。这项工作将提供可能导致干预措施的信息，将个人推向敏感性-弹性连续体的弹性端。

Behavioural and/or physiological responses to stressors enable an organism to deal effectively with the challenge, and regain homeostasis. While necessary, the stress response can lead to various deleterious effects in certain individuals. However, such effects are not observed in all individuals that are exposed to stress, or even extreme trauma, so, while it is important to uncover the mechanisms underlying vulnerability to the effects of stress, it is equally valid to pose the question - `what are the mechanisms at work in individuals that are resilient in the face of stress?' In the face of a changing environment, a variable coping strategy will be most effective for establishing an individual as being resilient, versus being vulnerable, to stress. We will examine the underlying mechanisms of coping and resilience using animal models. We will build on our past work and investigate the influence of key factors in the early and adolescent environment (parents, social structure) with respect to building coping behaviours in adulthood. We will also examine the underlying neural mechanisms. This work will provide information that could lead to interventions that move individuals toward the resilient end of the susceptibility-resilient continuum.