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Molecular characterization of the role of menin in embryonic development

Molecular characterization of the role of menin in embryonic development
Menin 在胚胎发育中作用的分子表征
批准号:
DP110105404
负责人:
Dr Graham Kay
金额:
$24.28万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2013-12-31

项目摘要

项目成果

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中文摘要
翻译
梅宁是一种防止肿瘤发展所必需的蛋白质。小鼠体内薄荷素的缺失会导致胚胎死亡。我们认为这是因为胎盘中的薄荷素是必需的。该项目将研究薄荷素在胎儿和胎盘中的作用,并提供如何控制正常妊娠和胎儿生长的信息。
英文摘要
Menin is a protein that is necessary to prevent development of tumours. Deletion of menin in mice causes embryonic death. We think this is because menin is necessary in the placenta. This project will examine the role of menin in the fetus and the placenta, and provide information about how normal pregnancy and fetal growth is controlled.
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会议论文
Understanding the development of pancreatic islet cell tumours
Transcriptional targets of the MEN1 tumour suppressor in endocrine cancer
Microarray analysis of Vegf-b knockout mice.
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