Transcriptional targets of the MEN1 tumour suppressor in endocrine cancer

我们通过灭活负责的肿瘤抑制基因，开发了一种称为多发性内分泌肿瘤1型（MEN 1）的人类癌症综合征的小鼠模型。这些小鼠在各种不同的组织中发展出肿瘤，包括胰腺、垂体、甲状旁腺和性腺。从该项目中获得的数据将是确定Men1基因作为肿瘤抑制因子的机制的第一步，并应阐明其在正常细胞周期调节中的作用。来自小鼠内分泌癌模型的发现将使人们更好地了解特别是MEN 1，以及一般的致癌作用。确定通常因MEN 1基因缺失而中断的细胞通路将有助于设计控制内分泌肿瘤和一些其他类型癌症的治疗方法。

We have developed mouse models of a human cancer syndrome called multiple endocrine neoplasia type 1 (MEN 1) by inactivating the tumour suppressor gene responsible. These mice devlop tumours of a wide variety of different tissues, including the pancreas, pituitary, parathyroids and gonads. The data obtained from this project will be the first major step towards determining the mechanism by which the Men1 gene functions as a tumour suppressor and should shed light on its role in normal cell cycle regulation. Findings from murine models of endocrine cancer will lead to a better understanding of MEN 1 in particular, and also of carcinogenesis in general. Defining the cellular pathways normally disrupted by loss of the MEN 1 gene will be useful in designing therapeutic approaches to control endocrine tumours and some other types of cancer.