Red Osier Dogwood extracts as alternatives to in-feed antibiotics to enhance growth performance and gut health in broiler chickens

禽肉的消费量一直在增加，主要是因为它对健康有好处，烹饪方便，**而且价格合理。2010年，全球食用动物生产中的抗菌剂消费量估计为63,151**吨，并有增加的趋势。这种做法与具有抗菌素耐药性的病原体在家禽和人类中的传播有关，构成了重大的公共健康威胁。自2006年以来，欧盟已经**禁止在动物性食品生产中使用抗生素生长促进剂，预计**加拿大很快就会这样做。在加拿大，持续需要帮助家禽业准备和实施减少抗生素的使用/消除预防性使用抗生素。红狗企业有限公司决定**与杨实验室合作，研究红木提取物作为饲喂抗生素的替代品，以**提高肉鸡的生长性能和肠道健康。对于目前的项目，已经确定了两个具体目标**。对于目标1，我们将测定饲喂不同水平山茱萸提取物的肉鸡的生长性能、器官重量和白色剥离的发生率。为实现目标2，我们将测定肉鸡在沙门氏菌脂多糖攻击后，饲喂不同水平的山茱萸提取物后的免疫反应、肠道微生物区系、氧化应激和炎症反应。拟议的Engage项目将支持初步研究，并在红狗企业有限公司和杨实验室之间架起桥梁。这笔资金将产生关于可能构成未来伙伴关系计划申请基础的**机制的新知识(例如：NSERC CRD)。

The consumption of poultry meat has been increasing mainly due to its health benefit, convenience in cooking,**and reasonable cost. Global consumption of antimicrobials in food animal production was estimated at 63,151**tons in 2010 with an increasing trend. This practice has been linked to the spread of antimicrobial-resistant**pathogens in both poultry and humans, posing a significant public health threat. The European Union has**banned the use of antibiotic growth promoters in animal food production since 2006 and this is expected in**Canada soon. There is an on-going need to help the poultry industry prepare for and implement the reduced use**of antibiotics/elimination of the preventive use of antibiotics in Canada. Red Dog Enterprises Ltd. has decided**to partner with the Yang lab to investigate Red Osier Dogwood extracts as alternatives to in-feed antibiotics to**enhance growth performance and gut health in broiler chickens. For the current project, two specific objectives**have been established. For Objective 1, we will determine the growth performance, organ weights and**occurrence of white stripping of broiler chickens fed different levels of Red Osier Dogwood extracts. For**Objective 2, we will determine the immune response, gut microbiota, oxidative stress, and inflammation in**broiler chickens fed different levels of Red Osier Dogwood extracts after Salmonella Lipopolysaccharide**challenge. The proposed Engage project will support preliminary research and bridge relations between Red**Dog Enterprises Ltd. and the Yang laboratory. This funds will yield new knowledge about putative**mechanisms that may form the basis of future partnership program applications (ie: NSERC CRD).