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Defining the molecular basis of regulation of PI3K gamma and its role in immune function and the tumour microenvironment

Defining the molecular basis of regulation of PI3K gamma and its role in immune function and the tumour microenvironment
定义 PI3K gamma 调节的分子基础及其在免疫功能和肿瘤微环境中的作用
批准号：
409575
负责人：
Burke John E
金额：
$69.66万
依托单位：
University of Victoria (British Columbia)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=409575&lang=en
关键词：
Crosslinking Mass Spectrometry Electron Microscopy Hydrogen Deuterium Exchange Mass Spectrometry Lipid Signalling Nanobodies Phosphoinositide 3-Kinases Phosphoinosities Protein-Protein Interactions Structure Based Drug Design X-Ray Crystallograph

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中文摘要
翻译
癌症治疗的主要发展之一是使用癌症免疫疗法，利用免疫系统靶向并摧毁癌细胞。磷酸肌肽3-激酶（PI3K）通路是癌症发生和肿瘤发生的十字路口
英文摘要
One of the major developments in cancer treatment has been the use of cancer immunotherapy to utilise the immune system to target and destroy cancer cells. The phosphoinositide 3-kinase (PI3K) pathway is at the crossroads of both cancer development and im
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