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Understanding what pretangle tau does to neurons and testing potential damage control by an anti-cis-ptau treatment

Understanding what pretangle tau does to neurons and testing potential damage control by an anti-cis-ptau treatment
了解 pretangle tau 对神经元的作用并测试抗 cis-ptau 治疗的潜在损伤控制
批准号:
408614
负责人:
Yuan Qi
金额:
$75.24万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-09-01 至 2024-09-01

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中文摘要
翻译
来自人类大脑的新证据表明,阿尔茨海默病可能发展的最早迹象是,即使在年轻时,脑干神经元中也会出现一种名为“前缠结tau”的蛋白质。这是老年痴呆症的主要症状之一
英文摘要
New evidence from human brains reveals that the earliest sign of the possible development of Alzheimer's Disease is the appearance of a protein called pretangle tau in brainstem neurons even at young ages. In older brains one of the major signs of Alzhei
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