Exercise oxidative metabolism in children.

尽管儿科运动生理学领域的文献不断涌现，但有关儿童和青少年运动期间调节氧化代谢的因素的知识仍然难以捉摸。我们对儿童运动氧化代谢的理解主要来自最大摄氧量的研究。儿童肌肉工作从休息到运动的过渡最好通过肺氧摄取（pVO 2）动力学反应进行评估，该反应受氧输送、提取和利用的调节。它是可能的，使用操作在工作到工作的过渡，踏板节奏和吸入氧的浓度，以非侵入性检查的上游（输送）或下游（提取和利用）的氧气摄取运输链的组件的影响。因此，在未来五年，我的目标是：（1）阐明影响年龄，性别和成熟对运动过程中pVO 2动力学反应的影响（2），通过分离上游的影响来确定基础外周机制，（交付）和下游（利用）氧摄取运输链（3）的组成部分，以实现这些发展世界一流的儿科“运动氧化代谢研究实验室在UBC Okanagan* 科学方法：* 参与者将是健康的青春期前（~8-10岁），青春期（12至16岁）和年轻人（18-24岁）。为了探索性别差异，所有组都将有50%的男孩。 我们将使用许多析因实验来探索中等强度和重强度运动过渡期间的pVO 2动力学反应（i）有和没有启动运动;（ii）在常氧（21%）和低氧（15%）吸气O2浓度期间，以及（iii）以55 rpm和115 rpm踏板时。** 新奇和重要性：* 这项研究计划将提供有关调节儿童对运动充满活力的挑战的氧化代谢反应的因素的新信息，这在女孩和男孩之间有何不同，以及随着儿童年龄的增长和成熟，这种变化如何。这些研究的结果将大大提高我们对性别差异反应的认识，以及生长发育对氧化功能的影响，这有可能影响儿童和青少年运动氧化代谢的现有理论。重要的是，这项工作将创造一个更好的证据基础，从中可以设计有效的干预措施，建立决定运动反应的生理因素，以及这些因素可以改变的程度。这将是发展未来研究的关键，研究由于疾病或环境而导致的氧化代谢受损。********

Despite the burgeoning literature in the field of pediatric exercise physiology, knowledge around the factors that regulate oxidative metabolism during exercise in children and adolescents remains elusive. Our understanding of exercise oxidative metabolism in the child has come mainly from studies of maximal oxygen uptake. The transitions in muscular work from rest to exercise in children are best assessed from the pulmonary oxygen uptake (pVO2) kinetic response, which is regulated by oxygen delivery, extraction and utilization. It is possible to use manipulations in work-to-work transitions, pedal cadence and the concentration of inspiratory oxygen to noninvasively examine the influence of upstream (delivery) or downstream (extraction and utilization) components of the oxygen uptake transport chain. Therefore, over the next 5 years, my objectives are to: (1) to elucidate the influence age, sex and maturation have on the pVO2 kinetic response during exercise (2) to identify underpinning peripheral mechanisms by isolating the impact of upstream (delivery) and downstream (utilization) components of the oxygen uptake transport chain (3) in achieving these develop a world-class pediatric `exercise oxidative metabolism' research laboratory at UBC Okanagan******SCIENTIFIC APPROACH: ***Participants will be healthy prepubertal (~8-10 years), pubertal (12 to 16 years) and young adults (18-24 years). To allow for sex differences to be explored all groups will be 50% boys. We will use a number of factorial experiments to explore the pVO2 kinetic response during moderate and heavy intensity exercise transitions (i) with and without priming exercise; (ii) during normoxic (21%) and hypoxic (15%) inspiratory O2 concentrations, and (iii) when pedaling at 55 rpm and at 115 rpm. ******NOVELTY AND SIGNIFICANCE:***This research programme will provide new information about the factors that regulate the oxidative metabolic response to the energetic challenges of exercise in the child, how this differs between girls and boys and how this changes as the child ages and matures. The results from these studies will significantly advance our knowledge of sex-differentiated responses and the influence growth and development have on oxidative function, which has the potential to influence current theories of exercise oxidative metabolism in the child and adolescent. Importantly this work will create a better evidence base from which effective intervention can be designed, establishing the physiologic factors that determine the response to exercise and the degree to which these can be altered. This will be key to developing future research investigating impaired oxidative metabolism due to disease or environment. ********