Characterization and optimization of new Silver based Antimicrobials

这项拟议的研究计划是由Exciton Technologies Inc.和McGill的化学系的科学家共同完成的。Exiton的科学家已经设计出一种新型的银基抗菌剂，用于伤口治疗。为了更好地表征这些新的衍生物，将研究一系列新的银(III)高碘酸络合物，并对其配方进行优化，以实现更持久和有效的抗菌活性。麦吉尔的工作将包括一系列先进技术，包括。X射线结晶学、拉曼光谱和固体核磁共振。用这些方法可以确定这些制剂的固态结构和溶液化学。然后，这些特性将以迭代的方式使用，以提高它们的抗菌效率和寿命。总而言之，这项工作有望改进一家充满活力的加拿大公司的产品，该公司将在许多临床和医院环境中用于先进的伤口治疗。

This proposed research program is between scientists at Exciton Technologies Inc. and McGill's department of chemistry. Exiton's scientists have devised a new class of silver based antimicrobial agents to be used in wound treatment. In an effort to better characterize these new derivatives a new series of silver(III) periodate complexes will be studied and their formulations optimized for more sustained and efficient antimicrobial activity. The work at McGill will include a range of advanced techniques including. X-ray crystallography, Raman Spectroscopy, and solid state NMR. With these methods the solid state structures and solution chemistry of these formulations will be determined. These properties will then be used in an iterative fashion to improve their antimicrobial efficiency and lifetimes. In all, this work is expected to improve on the product of a dynamic Canadian company which will be useful in many clinical and hospital setting for advanced wound treatment.