Applying our synthesis skills : natural products and molecular machinery

在我们的申请中有两个不同的研究项目，每个将依次总结。有机合成：***实践和发展合成科学是重要的努力。制药和农用化工等行业使用的是学术界开发的合成方法和试剂。此外，我们还提供训练有素的高素质人才。我们将努力准备几种天然产品：帕劳胺是一种复杂的天然生物碱，具有特别紧张的高能量片段，以难以制造而闻名；Plakortone和plakilactones是具有生物活性的聚酮家族的成员，是有前途的治疗药物。在尝试综合它们的过程中，我们将能够测试我们最近开发的方法的局限性，并发明新的方法。***分子开关：***合成的另一个目标是制备具有功能的有机分子（有机器件）。为了制造“智能设备”，该行业需要能够对环境做出反应或在受到刺激时完成工作的新型分子支架。我们提出了一种新的分子调制器，目的是对有用的系统进行控制。该系统将对外界刺激（光、热、化学物质等）作出反应。该系统依赖于控制两种称为区域异构体的物质之间的平衡。其目的是在施加外部刺激时从一个物种切换到另一个物种。如果我们把这个开关连接到一个功能系统上，比如一个显示荧光或导电的共轭系统，我们就能通过施加外部刺激来打开或关闭它。纳米材料和器件的制造潜力巨大。这两种支架将成为分子装置中为数不多但仍在不断增长的一种很好的补充。我们的项目将使所有需要合成材料的行业受益，无论是在方法方面还是在HQP方面。此外，我相信有机合成对材料化学有很大的贡献，我们希望在这个领域带来新的想法。

There are two distinct research programs in our application, each will be summarized in turn.***Organic synthesis:***Practicing and developing the science of synthesis are important endeavors. The pharmaceutical and agrochemical industries, among others, use synthetic methods and reagents that academics develop. In addition, we provide well trained and highly qualified people they can hire. We will endeavour to prepare several natural products: palau'amine is a complex natural alkaloid with a particularly strained high energy fragment notoriously difficult to make; plakortone and plakilactones are members of a biologically active family of polyketides that are promising therapeutics. In attempting their synthesis, we will be able to test the limits of our recently developed methodologies as well as invent new ones.***Molecular switches:***Another goal of synthesis is to prepare organic molecules possessing a function (organic devices). In order to make intelligent devices', the industry needs new molecular scaffolds that are able to respond to their environment or accomplish work when stimulated. We propose to make a novel molecular modulator with the aim of imparting control on useful systems. The system will respond to external stimuli (light, heat, chemicals, etc.). The system relies on controlling the equilibrium between to species called regioisomers. The aim is to switch from one species to the next upon applying an external stimulus. If we then hook' this switch onto a functional system, for example a conjugated system that displays fluorescence or conducts electricity, we would be able to turn it on' of off' by applying the external stimulus. There is immense potential in making nanomaterials and devices. The two scaffolds will be very good additions to a small but growing list of molecular devices.***Our program will benefit all industries that require synthetics, both in terms of methods and HQP. In addition, I believe that organic synthesis as a lot to contribute to material chemistry and we hope to bring new ideas in that field.