Chiral Systems Chemistry

手性系统化学*路易斯·巴斯德最出名的是巴斯德杀菌过程，通常与牛奶净化有关，但巴斯德对化学的贡献可能更深远。1848年，巴斯德仅凭肉眼观察就分离出了四水酒石酸铵的镜像晶体，并在这个过程中开创了分子不对称这一有趣的话题。手性，或用手，是我们日常生活的一部分，它的重要性在制药工业、农用化学品工业和食品工业中尤为明显。到2022年，手性技术产品的全球市场预计将达到91亿美元。生物分子的手性偏好是生命系统的一个特征，但生物同源性的起源是科学家面临的突出谜团之一，至今仍未找到确切的解释。*系统化学‘可以广义地定义为，从混乱中出现秩序’。将非手性分子凝聚结晶成手性晶体，为研究手性体系化学提供了独特的机会。我们实验室的实验表明，在一种称为Viedma成熟的过程中的磨损条件下，各种非手性分子的集合体晶体可以可靠地驱动到同质。我们研究的进展将涉及更深入地钻研手性系统化学，以了解手性结晶和自组装的层次性。我们的多层次方法包括：(I)实施促进Viedma成熟的现代机械力化学技术，(Ii)研究对映体特定定向连接(ESOA)，(Iii)探索凝胶中的手性结晶和螺旋形态发生，以及(Iv)超分子系统中镜像对称破缺和手性放大的研究。*我们的研究计划不仅对制药和农化行业至关重要，而且还解决了生物同质的起源这一陆地生命的基本分子特征的深刻问题。此外，我们对凝胶结晶的研究可能有助于更好地理解生物矿化作用，包括晶体的病理性沉积(即晶体沉积疾病)。

Chiral Systems Chemistry ******Louis Pasteur is best known for the process of pasteurization', typically associated with milk purification, but Pasteur's contribution to Chemistry is probably more far reaching. In 1848, Pasteur separated mirror image crystals of sodium ammonium tartrate tetrahydrate based solely on visual inspection, and in the process inaugurated the intriguing topic of molecular asymmetry. Chirality, or handedness, is part of our everyday lives and its importance is particularly evident in the pharmaceutical industry, the agrochemical industry, and the food industry. The global market for chiral technology-enabling products is projected to reach $9.1 billion by 2022. Chiral preference for one handedness of biomolecules is a characteristic of living systems, but the origin of biological homochirality is one of the outstanding mysteries facing scientists, where a precise explanation has yet to be found. ******Systems Chemistry' can be broadly defined as, the emergence of order from chaos'. Conglomerate crystallization of achiral molecules into chiral crystals provides a unique opportunity to investigate chiral systems chemistry'. Experiments in our lab have shown that under attrition conditions in a process called Viedma ripening', a wide variety of conglomerate crystals of achiral molecules can be reliably driven to homochirality. The evolution of our research will involve delving deeper into chiral systems chemistry' to understand the hierarchical nature of chiral crystallization and self-assembly. Our multi-tiered approach encompasses: (i) the implementation of modern mechanochemical techniques to facilitate Viedma ripening, (ii) the investigation of enantiomer-specific oriented attachment (ESOA), (iii) the exploration of chiral crystallization and helical morphogenesis in gels and (iv) the examination of mirror symmetry breaking and chiral amplification in supramolecular systems.******Our research program is not only of critical importance for the pharmaceutical and agrochemical industries, but also addresses the profound question as to the origins of biological homochirality, an essential molecular characteristic of terrestrial life'. Furthermore, our studies on crystallization from gels may contribute to a better understanding of biomineralization, including pathological deposition of crystals (i.e. crystal deposition diseases).*****