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Deciphering the molecular routes by which an altered sperm epigenome elicits birth defects in the offspring

Deciphering the molecular routes by which an altered sperm epigenome elicits birth defects in the offspring
破译精子表观基因组改变引起后代出生缺陷的分子途径
批准号：
416919
负责人：
Lismer Ariane
金额：
$7.65万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-11-01 至 2022-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=416919&lang=en
关键词：
Chip-Sequencing Craniofacial Birth Defects Embryogenesis Enhancer Functions In Development Epigenome Editing Histone Methylation Paternal Epigenetic Inheritance Rna-Sequencing Sperm Epigenome Ultra-Low-Input-Sequencing Technologies

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中文摘要
翻译
在加拿大，每25个婴儿中就有1个有先天缺陷。颅面畸形（头部和面部畸形）是最常见的出生缺陷，与婴儿死亡率高有关。新生儿颅面畸形
英文摘要
In Canada, 1 in 25 babies are born with a birth defect. Craniofacial abnormalities (head and face abnormalities) are the most prevalent class of birth defects and are associated with high rates of infant mortality. Infants born with craniofacial abnormali
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The effects of a paternal folate deficiency in a transgenic mouse model representative of a vulnerable population
  • 批准号：
    367227
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2016
  • 负责人：
    Lismer Ariane
  • 依托单位：
    McGill University
海外基金