Investigating the structural and functional architecture of the medial temporal lobe using advanced imaging

内侧颞叶(MTL)是大脑的一部分，负责许多重要的日常过程，如我们如何保留信息和建立记忆，我们如何处理我们的情绪，以及我们如何存储和使用关于其他人的信息。MTL不是单一的，而是由多个结构组成，这些结构相互通信，并与大脑的其余部分进行通信。对非人类灵长类动物的研究表明，MTL不同组成部分之间的通信模式决定了它们的功能。然而，在人类身上，人们对MTL的精细解剖及其连接知之甚少。*磁共振成像(MRI)硬件的最新发展为以前所未有的细节非侵入性评估人类大脑的解剖、连接和功能提供了新的机会。该项目的目标是使用在磁场为7Tesla的扫描仪上获得的超高分辨率图像来生成活体人类MTL的地图，这是目前魁北克和北美大部分地区可用的最强大的系统。7Tesla扫描仪获取的图像比普通扫描仪获取的图像要详细得多。*我们提议的项目将为加拿大顶尖大学的下一代科学家提供特殊的培训机会，并将使我们更好地了解我们是如何发展记忆、处理情绪和与他人互动的。**

The medial temporal lobe (MTL) is the part of the brain that is responsible for a number of important day to day processes, such as how we retain information and build memories, how we deal with our emotions, and how we store and use information about other people. The MTL is not single, but composed of multiple structures that communicate with each other and to the rest of the brain. Studies on non-human primates have shown that patterns of communication between various components of the MTL determine how they function. In humans, however, there is not much known about the fine anatomy of the MTL nor its wiring.****Recent developments in magnetic resonance imaging (MRI) hardware offer new opportunities to evaluate non-invasively human brain anatomy, wiring and function with unprecedented detail. The goal of this program is to produce a map of the living human MTL using ultra-high resolution images obtained on a scanner that has a magnetic filed of 7Tesla, the most powerful systems currently available within Quebec and across most of North America. Images acquired on a 7Tesla scanner are far more detailed than those obtained on ordinary scanners. ***The program we propose will provide exceptional training opportunities for the next generation of scientists at leading Canadian universities, and will allow to better understand how we develop memories, deal with emotions and interact with other people. **