Natural Product Synthesis and Synthetic Methodology

我的研究目的是开发25,917种合成方法。这些天然产物中的每一种都代表具有重要生物学性能的结构类型(MPC1001在体外试验中对前列腺癌细胞株具有极强的效力；考西酮抑制治疗相关的酶；山梨内酯A具有神经保护作用；CP 225,917具有与形成11元环的抗癌设计相关的生物活性，这是一个更容易的过程e MPC分子无疑将需要发明新的化学来响应相关中间结构的异常行为，LOP一般路线到烷氧基炔(ROCCR‘)-从酯制备苯类的方法，其方法是将酯羰基碳结合到苯环中，这一过程将在制备治疗糖尿病的药物中有用。

The aim of my research is to develop synthetic methods 25,917. Each of these natural products represents structural types with important biological properties (MPC1001 is extremely potent in in vitro tests against a prostate cancer cell line; coleophomone inhibits therapeutically relevant enzymes; sorbicillactone A is neuroprotective; CP 225,917 has biological activities relevant to the design of anticancer forming an eleven-membered ring, which is an easier process e MPC molecules will undoubtedly require the invention of new chemistry in response to the unusual behavior of the relevant intermediate structures, lop a general route to alkoxyalkynes (ROCCR') & methods for making benzenes from esters in a way that incorporates the ester carbonyl carbon into the benzene ringa process that will be useful in preparing drugs for treating diabetes.**