A novel bio-pesticide to control bacterial diseases on food crops-Phase 2

细菌性植物病原体降低作物产量，这意味着种植者的收入损失。控制粮食作物细菌感染的产品市场很大，全球每年花费3亿至5亿美元。现有的解决方案是铜基农药和二硫代氨基甲酸酯如代森锰锌的混合物。不幸的是，这些混合物是不够的，因为它们由于细菌病原体建立的抗性而具有下降的功效。此外，它们会通过胁迫植物来减少作物产量，使它们从一开始就减产。本项目的重点是利用生物技术开发创新的、具有市场竞争力的、环境可持续的作物保护产品，这些产品在控制粮食作物上的植物病原性黄单胞菌方面比市场标准更有效。生物农药是农业行业中增长最快的领域之一，受多种因素驱动：（a）消费者要求食品不含有毒农药，（B）各国政府正在响应其公民的要求，推动生物农药的开发和注册，作为替代品，（c）生产商正在积极寻找现有农药的替代品，传统产品的阻力问题。这个建议是一个正在进行的项目的延续。提出了几个里程碑，旨在最终开发基于产品的生物活性代谢物，这些代谢物由先前分离的细菌产生，证明可以抑制一系列植物病原性黄单胞菌属物种。将进行实地研究，在粮食作物上测试新产品。最后，我们将启动基于发酵的生产工艺的开发，并进行中试批次，为新产品的商业化做好准备。最终产品将是一种生物农药产品，满足加拿大市场的迫切需求。

Bacterial phytopathogens decrease crop yields, which translates to lost revenue for growers. The market for products that control bacterial infections on food crops is large, with annual spend of $300-500M worldwide. The incumbent solution is a mixture of copper-based pesticides and dithiocarbamates like mancozeb. Unfortunately, these mixtures are inadequate because they have falling efficacy due to resistance built up by bacterial pathogens. Furthermore, they can reduce crop yields by stressing plants, causing them to produce less from the outset. Finally, they cause significant environmental harm to soil and water.The focus of this project is to use biotechnology to develop innovative, market competitive, and environmentally sustainable crop protection products that are more efficacious than market standards in controlling phytopathogenic Xanthomonas bacteria on food crops. Bio-pesticides are one of the fastest growing segments in the agricultural industry, driven by a number of factors: (a) consumers are demanding food that is free of toxic pesticides, (b) governments are responding to the demands of its citizens, and pushing for the development and registration of bio-pesticides as an alternative, (c) producers are actively seeking substitutes for existing, conventional products given resistance issues.This proposal is the continuation of an ongoing project. Several milestones are proposed that will aim at finalizing the development of product based bioactive metabolites produced by previously isolated bacteria demonstrated to inhibit a range of phytopathogenic Xanthomonas species. Field studies will be performed to test the new products on food crops. Finally, we will initiate the development of a manufacturing process based on fermentation and run pilot batches to get the new products ready for commercialization. The final product will be a bio-pesticide products that fill pressing needs in the Canadian market.