Development of novel bio-pesticides to control bacterial diseases on food crops

开发新型生物农药来控制粮食作物的细菌性病害

• 批准号: 488896-2015
• 负责人: Déziel, Eric
• 金额: $ 11.36万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=619100
• 关键词: Development; novel; bio; pesticides; control

Bacterial phytopathogens decrease crop yields, which translates to lost revenue for growers. The market for products that control bacterial infections on food crops is large, with annual expenditures of $300-500M worldwide. The incumbent solution is a mixture of copper-based pesticides and dithiocarbamates like mancozeb. Unfortunately, these mixtures are inadequate because they have falling efficacy due to resistance built up by bacterial pathogens. Furthermore, they can reduce crop yields by stressing plants, causing them to produce less from the outset. Finally, they cause significant environmental harm to soil and water. The focus of this project is to use biotechnology to develop innovative, market competitive, and environmentally sustainable crop protection products that are more efficacious than market standards in controlling phytopathogenic Xanthomonas bacteria on food crops. Bio-pesticides are one of the fastest growing segments in the agricultural industry, driven by a number of factors: (a) consumers are demanding food that is free of toxic pesticides, (b) governments are responding to the demands of its citizens, and pushing for the development and registration of bio-pesticides as an alternative, (c) producers are actively seeking substitutes for existing, conventional products given resistance issues. This proposal is the continuation of an ongoing project in collaboration between INRS-Institut Armand-Frappier and Agri-Neo Inc. Three proposed milestones will aim at (1) confirming the activity and commercial potential of bioactive metabolites produced by previously isolated bacteria demonstrated to inhibit a range of phytopathogenic Xanthomonas, (2) identifying original bioactive metabolites by a metagenomic approach, and (3) isolating new biocontrol bacteria that will prevent infections by phytopathogens. Field studies will be performed to test the new products on food crops. Finally, we will develop a manufacturing process based on fermentation and run pilot batches to get the new products ready for commercialization. We will create a set of bio-pesticide products that fill needs in the Canadian market.

细菌性植物病原体降低作物产量，这意味着种植者的收入损失。控制粮食作物细菌感染的产品市场很大，全世界每年的支出为3亿至5亿美元。现有的解决方案是铜基农药和二硫代氨基甲酸酯如代森锰锌的混合物。不幸的是，这些混合物是不够的，因为它们由于细菌病原体建立的抗性而具有下降的功效。此外，它们会通过胁迫植物来减少作物产量，使它们从一开始就减产。最后，它们对土壤和水造成严重的环境危害。该项目的重点是利用生物技术开发创新的、有市场竞争力的、环境可持续的作物保护产品，这些产品在控制粮食作物上的植物病原性黄单胞菌方面比市场标准更有效。生物农药是农业中增长最快的部分之一，其驱动因素有：（a）消费者要求食品不含有毒农药，（B）政府正在响应公民的需求，推动生物农药的开发和注册，作为替代品，（c）生产商正在积极寻找现有传统产品的替代品，因为存在抗药性问题。该提案是INRS-Institut Armand-Frappier和Agri-Neo Inc.之间正在进行的合作项目的延续。三个拟议的里程碑将旨在（1）确认先前分离的细菌产生的生物活性代谢物的活性和商业潜力，这些细菌被证明能抑制一系列植物病原性黄单胞菌，（2）通过宏基因组方法鉴定原始生物活性代谢物，（3）分离新的生物防治细菌，以防止植物病原体感染。将进行实地研究，在粮食作物上测试新产品。最后，我们将开发一种基于发酵的生产工艺，并进行中试批次，为新产品的商业化做好准备。我们将创造一套生物农药产品，以满足加拿大市场的需求。