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Investigating the role of accelerated neuronal aging in a mouse model of Huntington's disease from a circadian epigenomic perspective.

Investigating the role of accelerated neuronal aging in a mouse model of Huntington's disease from a circadian epigenomic perspective.
从昼夜节律表观基因组角度研究亨廷顿病小鼠模型中神经元加速衰老的作用。
批准号:
437792
负责人:
Oh Gabriel Hyun Ta
金额:
$7.29万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2020
资助国家:
加拿大
项目状态:
已结题
起止时间:
2020-10-01 至 2021-10-01

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中文摘要
翻译
亨廷顿病(Huntington's disease,HD)是由亨廷顿基因中CAG核苷酸三联体扩增引起的脑部疾病。CAG扩张时间越长,疾病发作越早。然而,这种DNA突变并不能完全解释
英文摘要
Huntington's disease (HD) is a brain disease caused by an expansion of CAG nucleotide triplet in the huntingtin gene. The longer the CAG expansion, the earlier the onset of the disease. However, this DNA mutation does not fully explain the variability in
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Epigenetics of Major Depressive Disorder
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