100-Patient Ventilator for COVID-19

机械通气对于治疗受冠状病毒影响最严重的患者至关重要。在加拿大和世界上大多数国家，呼吸机的现有供应与预计需求之间的差距是1-2个数量级。短缺是极端的。虽然与药物和疫苗相关的时间表尚不确定，但患病人数和需要机械通气的人数越来越确定。世界各地都在努力提供呼吸机，我们在一个可共享的存储库中提供了对当前工作的全面回顾。当前努力的关键挑战是，每个病人一个系统的方法在数量、能力和可靠性上都无法扩展。问题的关键在于，每个病人一个系统的模式被打破了，但重要的病人定制是必不可少的。我们聘请了团队成员和呼吸专家Ewan Goligher为患者提供绝对最低的通气要求，并共同制定了这一挑战：一个系统如何为许多患者提供服务，同时为患者的需求和安全提供必要的床边定制？我们的解决方案——针对COVID-19的100患者呼吸机——支持集中气体处理，并在床边提供必要的气体控制。基本的病人可定制的操作参数是通过一个简单的流体控制单元设置。这种方法利用了集中式设施的有效性和效率，并降低了成本和复杂性。受到正在建设中的可容纳90-100名病人的约瑟夫·布兰特野战医院的启发，我们为100名病人设计了我们的系统，该系统将由10个呼吸机组成的10串连接，所有这些呼吸机都由一个集中的气体调节系统提供服务。这里的预算将用于开发、建设和测试两个字符串，每个字符串有10个患者单位，以及一个可容纳100名患者的中央系统。随着这一试点在2020年初取得成功，我们将有可能合作并扩大规模，在此次疫情中产生重大影响。

Mechanical ventilation is essential for the treatment of those most effected by coronavirus. The gap between the available supply of ventilators and the projected demand - in Canada and most countries worldwide - is 1-2 orders of magnitude. The shortage is extreme. While the timelines associated with drugs and vaccines are uncertain, the number of sick and the number in need of mechanical ventilation is increasingly certain. Many efforts are underway worldwide to provide ventilators, and we provide a comprehensive review of current efforts in a shareable repository. The key challenge with current efforts is that the one-system-per-patient approach will not scale in number, capability or reliability. The crux of the issue is that the one-system-per-patient model is broken, yet significant patient-customization is essential. We engaged team member and respiratory specialist Ewan Goligher to provide the absolute minimum requirements for patient ventilation and together formulated this challenge: How can one system provide for many patients, while enabling the essential at-bedside customization for patient needs and safety? Our solution - a 100-Patient Ventilator for COVID-19 - levers centralized gas processing and provides the essential gas control at the bedside. The essential patient-customizable operating parameters are set via a simple fluid control unit. This approach levers the effectiveness and efficiency of centralized facilities, and reduces cost and complexity. Inspired by the Joseph Brant field hospital under construction with capacity for 90-100 patients, we designed our system for 100 patients that will be connected in 10 strings of 10 ventilators - all served by a centralized gas conditioning system. The budget here will enable the development, building and testing of 2 strings with 10 patient units each, and a central system with capacity for 100 patients. With success of this pilot in early 2020, we will have the potential to partner and scale for major impact in this outbreak. With success of this pilot in early 2020, we will have the potential to make a major impact in this outbreak.