Investigating the mechanics of mRNA decapping in gene silencing

控制遗传物质的稳定性以调节生物 细胞分解机制控制遗传物质(信使RNA)的活动，而遗传物质反过来又是许多生物体合成蛋白质的模板。它有助于调节大多数生物过程，如脂肪新陈代谢、生殖细胞发育和许多其他过程。然而，目前还不清楚信使核糖核酸的去化机制如何与每个活细胞中的大量信使核糖核酸相互作用。我们正在研究信使RNA的去化机制是如何与特定的信使RNA结合的，以及一旦被招募，它是如何针对信使RNA进行降解的。我们相信，我们的研究计划将为这些基本机制如何运作以及最终它们如何帮助调节各种生物过程提供重要的见解。

Controlling the stability of genetic material to regulate biology The cellular decapping machinery controls the activity of genetic material (messenger RNA), which in turn serves as the template for the synthesis of proteins in many organisms. It helps regulate most, if not all, biological processes such as fat metabolism, germ cell development and many others. However, it is currently unclear as to how the mRNA decapping machinery interfaces with the numerous mRNAs in each living cell. We are studying how the mRNA decapping machinery interfaces with specific messenger RNAs, and how, once recruited, it targets a mRNA for degradation. We feel confident that our research program will provide important insights into how these fundamental mechanisms operate, and ultimately how they help regulate a variety of biological processes.