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Defining the repertoires and functional impacts of RNA binding proteins that undergo sequestration by toxic repeat RNA

Defining the repertoires and functional impacts of RNA binding proteins that undergo sequestration by toxic repeat RNA
定义被有毒重复 RNA 隔离的 RNA 结合蛋白的库和功能影响
批准号：
452179
负责人：
Lecuyer Eric
金额：
$59.63万
依托单位：
Institut de recherches cliniques de Montral
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-09-01 至 2026-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=452179&lang=en
关键词：
Drosophila Genetics Functional Dissection Neuromuscular Disorders Protein Sequestration Repeat Expansion Disorders Rna Binding Proteins Subcellular Trafficking Defects

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中文摘要
翻译
许多影响肌肉和/或神经系统的退行性疾病都是由一种类似的基因突变引起的，这种突变涉及到受影响印度人基因组中DNA碱基短片段（称为核苷酸重复）的重复扩增
英文摘要
Many degenerative diseases that affect muscles and/or the nervous system are caused by a similar type of genetic mutation involving the amplification of repetitions of short stretches of DNA bases, called nucleotide repeats, in the genome of affected indi
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