Identifying The Mechanisms That Specify Cell Size In Animal Cells.

细胞大小的规律性是健康上皮的典型特征，而大小规律性的丧失是多形性癌症的诊断。一个组织中的许多单个细胞是如何被调节成具有相同大小的？在前期工作中，我发现有证据表明，细胞大小的规律性是细胞大小依赖信号的产物，这种信号选择性地促进小细胞的生长，同时抑制大细胞的生长。当前建议的目的是确定细胞大小传感器的分子组成？细胞大小依赖的信号事件的机制。

Regularity of cell size is a classic signature of healthy epithelia while the loss of size regularity is a diagnostic of pleomorphic cancers. How are numerous individual cells within a tissue regulated to have the same size? In preliminary work, I identified evidence that regularity of cell size is the product of cell-size dependent signaling ¿ a signaling that selectively promotes growth of small cells while inhibiting growth in large cells. The aim of the current proposal is to identify the molecular components of the cell size sensor ¿ the mechanism of cell size dependent signaling events.