Organic And Organometallic Chemistry

提高人类生活质量和寿命的药理活性物质的发展对社会产生了巨大的社会影响。然而，与用于发现这些制剂的工具有关的固有限制阻碍了新药的开发，这也影响了新的农用化学品、材料等。例如，以可预测的方式制备新的药效团需要能够以系统的方式探索三维空间的多功能工具。该计划描述了新的成键反应的发展，这些反应获得了迄今未开发/探索的具有医学重要性的结构基序。

The development of pharmacologically active agents that improve the quality and longevity of human life has had an enormous societal impact on society. Nevertheless, the inherent limitations associated with the tools utilized to discover these agents has hampered the development of new medicines, which also impacts new agrochemicals, materials, etc. For instance, the preparation of a new pharmacophore in a predictable manner requires versatile tools that permit the exploration of three-dimensional space in a systematic manner. This program delineates the development of new bond-forming reactions, which access hitherto underdeveloped/explored structural motifs that are medicinally important.