Resolving the Structures of Human Muscarinic M1 and M4 Receptors.
Resolving the Structures of Human Muscarinic M1 and M4 Receptors.
批准号:
DP110100086
负责人:
Dr Elizabeth Scarr
金额:
$14.86万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2011
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2011-01-01 至 2014-12-31
中文摘要
毒蕈碱受体对大多数基本的人类大脑功能至关重要。这些受体在精神分裂症和阿尔茨海默病中发生了变化。该项目将确定其中两个受体的结构和定位,以便1)了解它们在脑部疾病中的作用,2)开发药物来治疗涉及它们的疾病。
英文摘要
Muscarinic receptors are vital for most basic human brain functions. These receptors are changed in schizophrenia and Alzheimer's disease. This project will determine the structure and localisation of two of these receptors in order to i) understand their roles in brain disorders and ii) develop drugs to treat disorders involving them.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Understanding the changes in brain chemistry associated with schizophrenia
-
批准号:FT100100689
-
项目类别:ARC Future Fellowships
-
资助金额:$56.3万
-
财政年份:2011
-
负责人:Dr Elizabeth Scarr
-
依托单位:
海外基金