Applying our synthesis skills : natural products and molecular machinery

在我们的申请中有两个截然不同的研究项目，每个项目都将依次总结。有机合成：实践和发展合成科学是重要的努力。制药和农化等行业使用学者开发的合成方法和试剂。此外，我们还为他们提供训练有素、高素质的员工。我们将努力制备几种天然产品：帕劳胺是一种复杂的天然生物碱，具有特别紧张的高能片段，众所周知，很难制造；普拉克内酯和普拉克拉内酮是具有生物活性的聚酮家族的成员，有望成为治疗药物。在尝试它们的合成时，我们将能够测试我们最近开发的方法的局限性，以及发明新的方法。分子开关：合成的另一个目标是制备具有功能的有机分子(有机器件)。为了制造“智能设备”，该行业需要新的分子支架，能够在受到刺激时对环境做出反应或完成工作。我们建议制作一种新型的分子调制器，目的是对有用的系统进行控制。该系统将对外部刺激(光、热、化学物质等)做出反应。该系统依赖于控制被称为区域异构体的TO物种之间的平衡。其目的是在施加外部刺激后从一个物种切换到下一个物种。如果我们将这个开关连接到一个功能系统上，例如一个显示荧光或导电的共轭系统，我们就可以通过施加外部刺激来打开它或关闭它。制造纳米材料和设备有着巨大的潜力。这两个支架将是一个很好的补充，分子设备的名单很小，但不断增加。我们的计划将使所有需要合成的行业受益，无论是在方法方面还是在HQP方面。此外，我相信有机合成对材料化学有很大的贡献，我们希望在这个领域带来新的想法。

There are two distinct research programs in our application, each will be summarized in turn. Organic synthesis: Practicing and developing the science of synthesis are important endeavors. The pharmaceutical and agrochemical industries, among others, use synthetic methods and reagents that academics develop. In addition, we provide well trained and highly qualified people they can hire. We will endeavour to prepare several natural products: palau'amine is a complex natural alkaloid with a particularly strained high energy fragment notoriously difficult to make; plakortone and plakilactones are members of a biologically active family of polyketides that are promising therapeutics. In attempting their synthesis, we will be able to test the limits of our recently developed methodologies as well as invent new ones. Molecular switches: Another goal of synthesis is to prepare organic molecules possessing a function (organic devices). In order to make `intelligent devices', the industry needs new molecular scaffolds that are able to respond to their environment or accomplish work when stimulated. We propose to make a novel molecular modulator with the aim of imparting control on useful systems. The system will respond to external stimuli (light, heat, chemicals, etc.). The system relies on controlling the equilibrium between to species called regioisomers. The aim is to switch from one species to the next upon applying an external stimulus. If we then `hook' this switch onto a functional system, for example a conjugated system that displays fluorescence or conducts electricity, we would be able to turn it `on' of `off' by applying the external stimulus. There is immense potential in making nanomaterials and devices. The two scaffolds will be very good additions to a small but growing list of molecular devices. Our program will benefit all industries that require synthetics, both in terms of methods and HQP. In addition, I believe that organic synthesis as a lot to contribute to material chemistry and we hope to bring new ideas in that field.