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Uncovering novel regulators of splenic hematopoiesis during cardiovascular disease

Uncovering novel regulators of splenic hematopoiesis during cardiovascular disease
发现心血管疾病期间脾造血的新调节因子
批准号：
473770
负责人：
Rasheed Adil
金额：
$3.28万
依托单位：
University of Ottawa Heart Institute
依托单位国家：
加拿大
项目类别：
Fellowship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-10-01 至 2023-10-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=473770&lang=en
关键词：
Atherosclerosis Bone Marrow Cell Death Hematopoiesis Hematopoietic Niche Hematopoietic Stem And Progenitor Cells Mixed Lineage Kinase Domain Like Protein Spleen

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中文摘要
翻译
在西方社会，心脏病是导致死亡的最大原因，其特点是血液中胆固醇升高和心脏炎症。动脉粥样硬化是心脏病的一种并发症，被认为是心脏血管狭窄
英文摘要
Heart disease is the greatest contributor to death in Western society and is characterized by increased blood cholesterol and inflammation in the heart. Atherosclerosis, a complication of heart disease, is recognized as a narrowing of vessels in the heart
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会议论文
Hyperlipidemia-induced Hematopoiesis is Repressed by MLKL in Endothelial Cells of the Splenic Niche
Knockdown of the Mixed Lineage Kinase Domain-Like Protein (MLKL) Enhances Extramedullary Hematopoiesis to Increase Atherosclerosis
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