C1 Building Blocks: Industrial Production of Water-Soluble Boron-Based Chromophores for Bio-Imaging Applications

我们最近重新利用了容易获得的氰基硼氢化钠，以制备新一代化学稳定的荧光含硼杂环化合物。该基础技术被收录在JACS的一篇论文中，随后获得了专利。我们委托Adventus Partners编写了一份技术评估报告，并根据获得的对我们想法的反馈，努力在我们提出的工作计划中满足行业的需求。这个里程碑式的项目的主要目标是开发一种强大的方法来获取新型荧光团，用于流式细胞术，超分辨率显微镜和荧光显微镜的下游应用。我们的平台技术C1Tech强调了中心sp2杂化碳原子对于构建高度可调的荧光杂环的战略意义，并将硼配置在战略位置。基于葡聚糖的Brilliant Matters将是该技术的主要受体。Brilliant Matters对含硼结构单元的商业化感兴趣，这些结构单元用于构建材料和生物成像应用的发色团。我们还将MilliporeSigma确定为这项新技术的另一种受体，以便将我们的研究结果推向市场。作为化学试剂领域的国际领先制造商，MilliporeSigma长期致力于将我们实验室中发现的试剂商业化。他们已经有了一个完全致力于Yudin实验室两性结构单元的门户网站，我们希望根据拟议的计划开发一个额外的杂环和材料门户网站。

We recently repurposed readily available sodium cyanoborohydride towards making a new generation of chemically stable fluorescent boron-containing heterocycles. The foundational technology was captured in a JACS paper and was subsequently patented. We commissioned a technology assessment report from Adventus Partners and, on the basis of the obtained feedback to our ideas, endeavoured to address the demands of industry in our proposed work plan. The main objective of this milestone-driven project is to develop a robust methodology to access novel fluorophores for their downstream use in flow cytometry, super-resolution microscopy, and fluorescence microscopy. Our platform technology, called C1Tech, stresses the strategic significance of the central sp2-hybridized carbon atom for the construction of highly tunable fluorescent heterocycles equipped with boron at a strategic position.Canadian-based Brilliant Matters will be the main receptor of this technology. Brilliant Matters is interested in commercialization of boron-containing building blocks for the construction of chromophores for materials and bioimaging applications. We have also identified MilliporeSigma as another receptor of this novel technology in order to market the results of our findings. MilliporeSigma, an international manufacturing leader in the area of chemical reagents, has shown a long-standing commitment to commercializing reagents discovered in our laboratories. They already have a web portal entirely dedicated to amphoteric building blocks from the Yudin lab and it is our expectation that there will be an additional portal to heterocycles and materials developed according to the proposed plan.