Environmental Fate of Emerging Contaminants

我的研究旨在提供最相关的信息，说明哪些新出现的污染物有可能对人类健康和环境造成影响和有害影响。我专注于污染物和问题，我的早期工作和科学文献显示，最有可能的风险。我总是很小心，不要简单地测量污染物的浓度，而是整合更多的机械研究，研究它们的行为和环境命运问题（转化，生物利用度和运输），它们对生物系统的影响以及我们可以修复或预防污染的方法。由于在测量这些污染物中的许多的超痕量水平方面的重大挑战，在将其应用于真实的世界基质之前，开发新方法和适当验证这些分析化学方法是至关重要的。我的重点将是对新出现的污染物及其代谢物和副产品的非目标分析。我打算扩大并继续开展对更多种类的蓝藻毒素进行分析的工作，扩大对全氟辛烷磺酸的分析工作。评价水和食物对接触蓝藻毒素和全氟辛烷磺酸的相对影响;综合代谢物、降解副产品的重要性以及与颗粒结合的污染物在饮用水中的作用，并权衡食物与水的相对影响和接触。我最近还获得了一个GC-HRMS Orbitrap系统，并将开发用于测量较少的亲脂性全氟辛烷磺酸、蓝藻毒素的新方法，并将热解系统用于分析水、沉积物、土壤改良剂和生物组织中的塑料聚合物。分析目的：我计划使用HRAM-MS来进一步提高我们进行非目标分析的分析能力，并开发方法来回顾性地质疑存档的全扫描HRAM-MS，以提供浓度的半定量估计。我试图开发程序，就如何最好地做初步分析，以最佳的数据存档价值。我还将运用我在LC-HRAM-MS方面的专业知识，将分析开发与HRAM-MS GC-Orbitrap方法相结合。 我们还将能够使用非目标GC分析来寻找使用LC难以分析的PFAS副产品，农药和药物残留。我还想将联合收割机GC-Orbitrap系统与热解界面结合起来，在我的实验室中开发针对塑料聚合物（包括降解副产物）的专业知识。环境目标：我将重点讨论三个问题：1）全氟辛烷磺酸在生物体中的生物累积; 2）蓝藻毒素的生物累积、转化和转移; 3）对水中塑料聚合物及其降解副产品的痕量水平进行量化。和其他矩阵

My research seeks to provide the most relevant information on which emerging contaminants have the potential to cause impact and deleterious effects for human health and the environment. I focus on contaminants and problems for which my earlier work and the scientific literature shows the most potential for risks. I am always careful not to simply measure concentrations of contaminants but integrate more mechanistic studies of their behavior and environmental fate issues (transformation, bioavailability and transport), their impacts on biological systems and the means through which we can remediate or prevent the pollution. Because of the significant challenge in measuring the ultratrace levels of many of those contaminants, development of new methods and proper validation of such analytical chemistry methods are critical before their application to real world matrices. My focus will be on non-target analysis of emerging contaminants and their metabolites and by-products. I intend to expand and pursue the work on the analysis of an expanded range of cyanotoxins, expand the work on the analysis of PFOS. Evaluate the relative contribution of water and food to the exposure to cyanotoxins and PFOS; integrating the importance of metabolites, degradation by-products and the role of particulate-bound contaminants in drinking water and weighing the relative impacts and exposure coming from food vs. water. I have also just recently acquired a GC-HRMS Orbitrap system and will develop new methods for the less measured lipophilic PFOS, cyanotoxins and also integrate the use of the pyrolysis system for the analysis of plastic polymers in water, sediments, soil amendments and biological tissues. Analytical objectives: I plan to use HRAM-MS to further enhance our analytical capacity to do non-target analysis and develop methods to retrospectively question archived full-scan HRAM-MS to provide semi-quantitative estimates of concentrations. I seek to devellop procedures on how to best do the initial analysis for optimal data archiving value. I will also apply my expertise with LC-HRAM-MS to integrate analytical developments with HRAM-MS GC-Orbitrap methods.  We will also be able to use non-target GC analysis to seek out by-products of PFAS, pesticides and pharmaceutical residues that are difficult to analyse using LC. I also want to combine the GC-Orbitrap system with a pyrolysis interface to develop an expertise in my lab to target plastic polymers including degradation by-products. Environmental objectives:  I will focus on three issues; 1) bioaccumulation of PFOS into organisms; 2) bioaccumulation, transformation and transfer of cyanotoxins; 3) quantify trace levels of plastic polymers and their degradation by-products that occur in water. and other matrices