Investigating the use of a novel Dualase (dual-endonuclease) system in repairing nonsense mutations and restoring CFTR expression in cystic fibrosis mouse and human airway models
Investigating the use of a novel Dualase (dual-endonuclease) system in repairing nonsense mutations and restoring CFTR expression in cystic fibrosis mouse and human airway models
研究使用新型 Dualase（双核酸内切酶）系统修复囊性纤维化小鼠和人类气道模型中的无义突变并恢复 CFTR 表达
批准号：
486584
负责人：
Antonio Krista
金额：
$1.27万
依托单位：
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-12-01 至 2023-12-01
中文摘要
翻译
囊性纤维化（CF）是一种单基因疾病，主要影响消化系统和肺部。这种疾病的并发症包括肺内粘稠的粘液积聚，导致呼吸困难，以及营养吸收过程中的营养不良。
英文摘要
Cystic fibrosis (CF) is a monogenic disease that mainly affects the digestive system and lungs. Complications of the disease include thick mucus buildup in the lungs resulting in difficulty in breathing as well as malnutrition from nutrient absorption pro
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