EXploring seX-specific gene regulation: Analyzing DNA damage and silencing by characterizing structural variants on the X chromosome
EXploring seX-specific gene regulation: Analyzing DNA damage and silencing by characterizing structural variants on the X chromosome
批准号:
486574
负责人:
Boev Nadejda B
金额:
$1.27万
依托单位:
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2022
资助国家:
加拿大
项目状态:
已结题
起止时间:
2022-12-01 至 2023-12-01
中文摘要
在人类早期发育中,与XY个体不同,XX染色体个体随机沉默一条X染色体作为补偿拥有两条X染色体的策略。在某些情况下,DNA可能会受损,并引入基因组结构变异(SVs),
英文摘要
In early human development, XX chromosome individuals randomly silence one X chromosome as a strategy to compensate for having two X chromosomes, unlike XY individuals. In some cases, DNA can become damaged and introduce genomic structural variants (SVs),
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