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Defining the mechanisms underlying the sex bias of neurodevelopmental disorders in preclinical models of autism spectrum disorder (ASD)

Defining the mechanisms underlying the sex bias of neurodevelopmental disorders in preclinical models of autism spectrum disorder (ASD)
定义自闭症谱系障碍 (ASD) 临床前模型中神经发育障碍性别偏见的机制
批准号:
477874
负责人:
Swift-Gallant Ashlyn
金额:
$67.99万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-03-01 至 2028-03-01

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中文摘要
翻译
男性患自闭症谱系障碍(ASD)的可能性是女性的4倍,这表明性发育的生物学(即性染色体和激素)与ASD风险有关。我们的实验室已经在临床前证明了男性在自闭症风险方面的偏见
英文摘要
Males are 4X more likely than females to develop autism spectrum disorder (ASD), suggesting that the biology of sex development (i.e., sex chromosomes and hormones) contributes to ASD risk. Our lab has demonstrated a male bias in ASD risk in a preclinical
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