Presynaptic mechanisms of general anaesthesia in the fly brain

全身麻醉是人类和兽医手术的常规程序，也是任何需要动物固定的实验范例的常规程序。通过消除意识，这些药物为从业者提供了一种理想的方式，在反应性可能不受欢迎的情况下操纵受试者。了解操纵突触释放机制可能如何调节麻醉效力，对于最终能够更好地控制人类和动物受试者的麻醉状态将是有价值的。通过了解大脑功能的多个层次的全身麻醉，我们将同时回答与感知和意识机制有关的基本问题。

General anaesthesia is a routine procedure for both human and veterinary surgery and for any experimental paradigms requiring immobilization of animals. By abolishing consciousness, these drugs provide practitioners with an ideal way of manipulating subjects under conditions when responsiveness might be undesirable. Understanding how manipulating synaptic release mechanisms might modulate anaesthetic potency will be valuable for eventually being able to better control the anaesthetized state in human and animal subjects. By understanding general anaesthesia across multiple levels of brain function, we will at the same time be answering fundamental questions pertaining to mechanisms of perception and awareness.