Renal Tubule-Specific Angiotensinogen Knockout Ameliorates Diabetic Kidney Disease in Type 1 Diabetic Akita Mice
Renal Tubule-Specific Angiotensinogen Knockout Ameliorates Diabetic Kidney Disease in Type 1 Diabetic Akita Mice
批准号:
495591
负责人:
Yang Wenxia
金额:
$0.11万
依托单位国家:
加拿大
项目类别:
财政年份:
2023
资助国家:
加拿大
项目状态:
已结题
起止时间:
2023-09-01 至 2024-09-01
关键词:
中文摘要
背景:血管紧张素原(AGT)是肾素-血管紧张素系统(RAS)中血管紧张素的唯一前体,在糖尿病肾病(DKD)小鼠和患者的肾脏近端小管(RPT)中高表达。我们之前报道过,老鼠
英文摘要
Background: Angiotensinogen (AGT), the sole precursor of angiotensins in the renin-angiotensin system (RAS), is highly expressed in the renal proximal tubules (RPTs) of mice and patients with diabetic kidney disease (DKD). We reported previously that mice
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