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Apnea, sex and FMO: Are flavin-containing monooxygenases the new anti-ox that prevent metabolic disorders under intermittent hypoxia?

Apnea, sex and FMO: Are flavin-containing monooxygenases the new anti-ox that prevent metabolic disorders under intermittent hypoxia?
呼吸暂停、性和 FMO:含黄素单加氧酶是预防间歇性缺氧下代谢紊乱的新型抗氧化酶吗?
批准号:
487678
负责人:
Joseph Vincent
金额:
$46.26万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-09-01 至 2028-09-01

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中文摘要
翻译
睡眠呼吸暂停是一种常见的呼吸系统疾病,当呼吸道关闭时,流向肺部的气流受阻。在阻塞期间,血液中的氧气水平会下降,然后随着呼吸的重新开始,血液中的氧气水平会突然恢复正常。这种模式
英文摘要
Sleep apnea is a common respiratory disorder occurring as the airflow to the lungs is obstructed by the closure of the airways. During obstructions, oxygen levels in the blood drop then abruptly return to normal as breathing starts again. This pattern of
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Sex and sex-hormones determine pulmonary morphological and single-nucleus transcriptomic responses in an animal model of sleep apnea.
  • 批准号:
    494508
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2023
  • 负责人:
    Joseph Vincent
  • 依托单位:
Estradiol receptor alpha mediates sex-specific responses in an animal model of sleep apnea.
  • 批准号:
    389766
  • 项目类别:
    Operating Grants
  • 资助金额:
    $46.26万
  • 财政年份:
    2018
  • 负责人:
    Joseph Vincent
  • 依托单位:
Age- and sex-specific contribution of nuclear or membrane progesterone receptors on respiratory control in mice.
  • 批准号:
    265347
  • 项目类别:
    Operating Grants
  • 资助金额:
    $44.27万
  • 财政年份:
    2012
  • 负责人:
    Joseph Vincent
  • 依托单位:
A critical role of progesterone for development of respiratory control system.
  • 批准号:
    188430
  • 项目类别:
    Operating Grants
  • 资助金额:
    $26.94万
  • 财政年份:
    2009
  • 负责人:
    Joseph Vincent
  • 依托单位:
海外基金