Transporting proteins to and within mitochondria

线粒体存在于我们所有的细胞中，对生命至关重要。它们就像一个核电站，提供大量的能量，但如果线粒体壁（膜）被打开，它们也会杀死细胞。线粒体含有大约1000种不同的蛋白质才能正常工作，但几乎所有这些蛋白质都是在隔室外形成的，必须通过狭窄的膜通道挤进去。该项目将为蛋白质如何进入线粒体以及哪些因素在这一过程中起作用提供新的见解。除了提供对生命至关重要的过程的新信息外，该项目还将训练学生掌握分子细胞生物学技术，并有助于促进强有力的国际合作。

Mitochondria are found in all of our cells and are essential for life. They act like a nuclear power plant, providing the bulk of energy - but they can also kill the cell if the mitochondrial wall (membrane) is opened. Mitochondria contain about 1000 different proteins to function properly but almost all of them are made outside the compartment and must squeeze in through narrow membrane channels. This project will provide new insights into how proteins get into mitochondria and what factors help in this process. Besides providing new information about a process that is essential for life, the project will train students in molecular cellular biology techniques and will help foster strong international collaborations.