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Tissue-engineered humanized model of the gastric tumor microenvironment to mechanistically evaluate the dynamics of combined tumor-infiltrating lymphocyte and RNA nanoparticle therapy

Tissue-engineered humanized model of the gastric tumor microenvironment to mechanistically evaluate the dynamics of combined tumor-infiltrating lymphocyte and RNA nanoparticle therapy
胃肿瘤微环境的组织工程人源化模型，用于机械评估肿瘤浸润淋巴细胞和 RNA 纳米颗粒联合治疗的动力学
批准号：
490149
负责人：
Kinsella Joseph
金额：
$76.63万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2028-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=490149&lang=en
关键词：
Bioprinting Imaging Mass Cytometry In Vitro Bioengineered Cancer Model Nanomedicine Pharmacometrics Rna Therapeutics T-Cell Therapy Tissue Engineering Transcriptomics Tumour-Infiltrating Lymphocytes

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中文摘要
翻译
当细胞毒性免疫细胞遇到肿瘤时，由于肿瘤为躲避攻击而建立的密集蛋白质环境，它们被排除在肿瘤之外。在这个提议中，我们将创建
英文摘要
When cytotoxic immune cells encounter a tumor they are excluded from entering it due to the dense protein environment that the tumor builds to evade being attacked. In this proposal, we will create personalized models of gastric cancer to study the mecha
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