基于表面修饰的中药粉体亲水性调控工艺设计与系统评价：以青黛为例

粉体改性技术可针对性改变粉体的物理或化学性质，改善其应用性能。青黛在古今中医临床用法发生了重大变化，入汤剂成为主流，但青黛的强疏水性严重影响了汤剂中药物的分散性，制约了临床疗效。课题组拟采用改性技术，以青黛表面润湿性修饰转变为突破，提高亲水性，制备适宜汤剂给药的新型青黛粉体。.在前期青黛化学成分、产地加工原理及改性技术研究基础上，拟采用接触角-润湿热-表面自由能及其分量-表面元素与官能团的评价体系，对青黛进行吸附接枝、成膜及粒子包覆三条改性工艺研究，从宏观现象与微观机制、物理变化与化学本质、热力学与动力学基础三个方面系统评价改性对润湿过程的影响及其机理，建立表面性质的多维评价体系；从“改性剂-改性设备-工艺参数”过程链优化改性工艺、总结改性规律；并进行性-效-用系统评价，确保改性青黛安全、有效、稳定、顺应。本研究对于促进青黛饮片的发展升级，提升中药粉体加工技艺，具有重要临床价值与实践意义。

Powder modification technology can be targeted to change the physical or chemical properties of the powder to improve its application performance.significant changes have taken place in the ancient and modern TCM clinical usage of Indigo naturalis, Indigo naturalis decoction has become a mainstream. However, the actual intake and clinical efficacy of Indigo naturalis was seriously influenced because of the strong hydrophobicity.The research group intends to use modification technology to modify and change the wetting modification of indigo surface, improve the hydrophilicity, and prepare the new type of indigo powder for proper decoction.. Based on preliminary studies, the evaluation system of contact angel-wetting heat-surface free energy and its components surface elements -functional groups is adopted, three modification technologies of adsorption grafting, film forming and particles covering in Indigo naturalis are investigated, from three categories of macro phenomenon and micro mechanism, physical changes and chemical nature, thermodynamic and kinetic foundation, modification influence on wetting process and its principle are assessed systematically, the multidimensional evaluation system about surface properties is established;he procedure chain pertaining to “modifiers-modifying equipment-technological parameters” is used to optimize the modification process and summary the modified rules;And the task force also conducted a systematic evaluation of performance - effect - the use , to ensure that the modified indigo safe, effective, stable, compliant.This study has important clinical value and practical significance for promoting the development and upgrading of indigo slices and improving the traditional Chinese medicine processing skills.