From natural dye to herbal medicine: a systematic review of chemical constituents, pharmacological effects and clinical applications of indigo naturalis.
From natural dye to herbal medicine: a systematic review of chemical constituents, pharmacological effects and clinical applications of indigo naturalis.
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从天然染料到草药：青黛化学成分、药理作用及临床应用的系统综述
DOI：
10.1186/s13020-020-00406-x
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发表时间：
2020-12-14
期刊：
影响因子：
4.9
通讯作者：
Chun-Guang X
中科院分区：
文献类型：
--
作者：
Qi-Yue Y;Ting Z;Ya-Nan H;Sheng-Jie H;Xuan D;Li H;Chun-Guang X
青黛是一种古老的蓝色染料，也是一种用途广泛的中药。它具有广泛的药理作用，可用于治疗白血病、牛皮癣和溃疡性结肠炎等多种疾病。本文旨在加深对青黛的化学成分、药理作用和临床应用的了解。应用计算机检索PubMed、Web of Science、CNKI、Google Academy、Elsevier等数据库，检索词为“Indigo insitialis”，并根据研究结果对现代青黛的研究进行综述和整理。概述了青黛的传统炮制工艺、化学成分和质量控制，系统综述了青黛的传统用途、药理活性和作用机理，总结了青黛治疗银屑病、白血病和溃疡性结肠炎的临床试验。青黛具有抗炎、抗氧化、抗菌、抗病毒、免疫调节等多种药理活性。对银屑病、白血病、溃疡性结肠炎有很好的临床疗效。但需要注意的是，长期服用青黛可能会产生一些可逆的不良反应。综上所述，青黛是一种非常重要的药物，具有很大的价值和潜力。
Indigo naturalis is a blue dye in ancient, as well as an extensive used traditional Chinese medicine. It has a wide spectrum of pharmacological properties and can be used to treat numerous ailments such as leukemia, psoriasis, and ulcerative colitis. This article aims to expand our understanding of indigo naturalis in terms of its chemical constituents, pharmacological action and clinical applications. We searched PubMed, web of science, CNKI, Google academic, Elsevier and other databases with the key words of “Indigo naturalis”, and reviewed and sorted out the modern research of indigo naturalis based on our research results. We outlined the traditional manufacturing process, chemical composition and quality control of indigo naturalis, systematically reviewed traditional applictions, pharmacological activities and mechanism of indigo naturalis, and summarized its clinical trials about treatment of psoriasis, leukemia and ulcerative colitis. Indigo naturalis has a variety of pharmacological activities, such as anti-inflammatory, antioxidant, antibacterial, antiviral, immunomodulatory and so on. It has very good clinical effect on psoriasis, leukemia and ulcerative colitis. However, it should be noted that long-term use of indigo naturalis may produce some reversible adverse reactions. In summarize, indigo naturalis is an extremely important drug with great value and potential.
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影响因子：
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作者：
Cheng HM;Wu YC;Wang Q;Song M;Wu J;Chen D;Li K;Wadman E;Kao ST;Li TC;Leon F;Hayden K;Brodmerkel C;Chris Huang C
通讯作者：
Chris Huang C
影响因子：
13.6
作者：
Aten, J;Roos, A;Weening, JJ
通讯作者：
Weening, JJ
影响因子：
2.6
作者：
Chen, D-Y;Chen, Y-M;Lan, J-L
通讯作者：
Lan, J-L
影响因子：
7.3
作者：
Bandekar, Pooja P.;Roopnarine, Keir Alekseii;Sinden, Richard R.
通讯作者：
Sinden, Richard R.
溃疡性结肠炎。
DOI：
10.1016/s0140-6736(16)32126-2
发表时间：
2017-04-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Ungaro R;Mehandru S;Allen PB;Peyrin-Biroulet L;Colombel JF
通讯作者：
Colombel JF