基于营卫理论探讨寤寐昼夜节律对老年轻度认知功能障碍的影响及生态瞬时评估模型研究

睡眠-觉醒昼夜节律紊乱被证实是老年人认知功能障碍的风险因素之一，中医认为营卫昼夜节律是睡眠活动的机枢，而通调营卫讲究因时制宜。课题组前期证实因时制宜干预痴呆大鼠模型可取得显著的疗效。然而，目前国内外多关注老年痴呆与昼夜节律之间的研究，评估时间节点滞后，也未考虑到整体、动态、个性化的特点。我们提出问题：老年轻度认知功能障碍（MCI）寤寐昼夜节律的阴阳消长、气血营卫运行规律是如何改变的，是否存在“因时制宜”的关键时间窗口？为此，本项目拟面向MCI相关性睡眠障碍人群，采用具有自主知识产权的低成本、柔性贴敷式应力及血氧光电传感器芯片，精准采集高信噪比的睡眠及生理信号，融合人工智能评估决策与推断技术，构建生态瞬时评估模型。探讨MCI病因防治的最佳时机，重点阐明寤寐昼夜节律的阴阳消长、气血营卫运行的特征变化，并据此制定具有中医理论内涵的康复方案，更好地发挥中医养生与康复原创思维的优势，应用前景广阔。

Sleep-wake circadian rhythm disorder has been proven to be one of the risk factors for cognitive dysfunction in the elderly. Traditional Chinese medicine believes that circadian rhythm of Ying Qi and Wei Qi for day and night is the internal basic for sleep activities,while regulating Ying Qi and Wei Qi should be adapted to the theory of “treatment in accordance with seasonal condition”. The research group confirmed in the early stage that it can obtain significant curative effect in the intervention in rat model of dementia. However, at present, more attention has been paid to the research between senile dementia and circadian rhythm at home and abroad, and the evaluation of time node lag. They also don’t consider the overall, dynamic, and personalized characteristics. We raise the following questions: how does Yin-Yang Waxing and Waning of circadian rhythm of sleep and circulation of Qi-Blood and Ying Wei in the elderly with mild cognitive impairment(MCI) change, how does the operation law of Qi-Blood and Ying Wei change, and whether there is a key time window of "treatment in accordance with seasonal condition"? Therefore, this project is intended for people with MCI-related sleep disorders, using low-cost, flexible application stress and blood oxygen photoelectric sensor chips with independent intellectual property rights to accurately collect sleep and physiological signals with high signal-to-noise ratio (SNR). The ecological instantaneous assessment model is constructed by combining artificial intelligence evaluation decision-making and inference technology.