过饱和多甲氧基黄酮纳米乳构建及其亚稳态调控研究

多甲氧基黄酮(PMFs)等一大类脂溶性活性组分因其易结晶、水溶性低的限制，严重制约了其生物可利用性，甚至导致超量食用而产生局部毒性。构建高荷载功能性组分递送体系并保持其在消化环境下稳定，是食品营养与食品配料领域重要科学问题。本课题拟以具结晶性和低水溶性的PMFs为代表性脂溶性组分，从其分子结构及溶解性差异出发、利用与生物大分子的组分相互作用，创建PMFs过饱和溶解体系，探究其影响因素与维持方法，在此基础上制备过饱和PMFs乳液，表征其稳定性及负载率，评估其体内外的生物可利用性及安全性。课题研究可为重要生理活性物质 PMFs 的食品应用提供直接的理论和数据支持，更可为一大类兼具结晶性和脂溶性的功能组分的有效输送提供方法的借鉴和研究思路的参考。

The bioavailability of polymethoxyflavones (PMFs) and such lipophilic bioactive components is seriously limited due to their crystalline and low water-solubility, which might cause local toxicity as for the excess ingestion. To fabricate high-loading delivery systems of functional ingredients and maintain the their stability under digestion tract, is the important scientific issue in the field of food nutrition and food ingredients. In this project, polymethoxyflavones (PMFs) with crystallinity and poor water-solubility are chosen as typical lipophilic components. The PMFs supersaturated dissolution systems will be created by investigating the difference of molecular structure and solubility, and studying the interaction with biopolymers. Then the influence factors and maintenance strategies are exploited. Subsequently, the supersaturated PMFs emulsions are prepared and their stability and encapsulation efficiency are characterized. Finally, the in vitro and in vivo bioavailability and safety are evaluated. This research can not only provide direct theoretical and data support for the food application of important physiological active components PMFs, but also offer referential methods and ideas for effective deliver of crystalline and lipophilic functional components.