应用于磁粒子成像的超高灵敏度检测线圈研究

磁粒子成像（Magnetic Particle Imaging, MPI）是一种利用超顺磁性氧化铁纳米粒子（Superparamagnetic Iron Oxide Nanoparticles, SPION）进行人体内造影的新兴方法，其具有成像速度快，无有害电离辐射，造影剂毒副作用小等特点。本项目以提高MPI检测灵敏度为目标，并以申请人前期在国外的科研工作为基础，对降低MPI检测线圈的内外部噪声的方法分别进行深入研究。对于外部噪声，拟基于Gradiometer结构，对激励线圈干扰、梯度线圈干扰等多种来源噪声进行建模分析；对于内部噪声，拟对铜Litz线及高温超导线MPI检测线圈的交直流损耗及机械性能等进行建模分析；在此基础上，系统性地设计线圈噪声的解决方案并进行成像实验以确认本研究的有效性。本项目的预期研究成果可实现世界范围内领先的MPI检测灵敏度，为MPI走向临床领域做出重要贡献。

Magnetic Nanoparticle Imaging (MPI) is a new method of using Superparamagnetic Iron Oxide Nanoparticles (SPION) for in-vivo diagnosis. MPI has fast imaging speed, no harmful ionizing radiation and the SPION contrast agent has little toxic and side effects. This project aims to improve the sensitivity of MPI detection based on the applicant's previous research work abroad, and conducts in-depth research on the internal and external noise of the MPI pick-up coil. For the external noise, it is proposed to model and analyze the noise from multiple sources such as excitation coil and gradient coil based on the Gradiometer pick-up coil structure; for the internal noise, it is planned to model and analysis the AC loss, mechanical properties and other important parameters of the MPI pick-up coil made of the copper Litz wire and high-temperature superconducting wire. Further, a systematically design of the pick-up coil and experimental test will be taken to confirm the effectiveness of this study. The expected research results of this project can achieve the best MPI detection sensitivity in the world, and make important contributions for the MPI to the clinical field.