基于"肺气虚失治节"理论的慢性阻塞性肺疾病K-ATP通道抑制与肺血管收缩机制的研究

肺主治节是对肺生理功能的高度概括，治节功能是通过肺主气而行使的，肺气虚则肺失治节，顺次发生的"气虚痰凝血瘀"是多种肺系疾病如肺胀等的关键病理环节和重要发病机理。多年研究表明，肺失治节可以应用中药干预进行治节重建。既往研究发现益气化痰祛瘀方药是实现治节重建的最有效途径，但其作用机理尚待探讨。现代研究证实，肺血管收缩是肺胀（COPD）并发肺动脉高压的主要机制，而低氧是抑制K-ATP通道导致肺血管收缩根本原因。COPD肺气虚失治节是抑制K-ATP通道致肺血管收缩的主要病机。本研究选择COPD痰瘀阻肺证模型大鼠，通过有效干预，实现治节重建以此调控K-ATP通道，抑制肺血管收缩，降低肺动脉高压，从而进一步明确"肺主治节"理论内涵及对COPD防治的指导作用，阐明COPD治节重建过程中K-ATP通路与肺血管收缩相互关系，揭示中医药干预COPD肺血管收缩的起效途径和作用靶点，创新和丰富中医药理论。

Theory of〝Lung Governing Management and Regulation〞highly generalized physiological functions of the lungs. if there is enough Lung qi,Lung can rule the action of Management and Regulation.nevertheless,if Lung qi Deficiency,Lung missed the action of Management and Regulation.〝Qi deficiency,phlegm and blood stasis〞is important pathogenesis about a variety of pulmonary diseases,such as COPD.Years of research shows that〝Lung missed the action of Management and Regulation〞can reconstruction by Intervention of traditional Chinese Medicine. Our previous study found,prescriptions Treatment for phlegm and blood stasis is the most effective way to achieve reconstruction of 〝Lung Governing Management and Regulation〞, But the mechanism still need to discuss.Modern research confirms, pulmonary vasoconstriction is the major mechanism of COPD complicated with pulmonary hypertension,while hypoxia is the root cause of inhibiting the K-ATP channel leading to pulmonary vasoconstriction. We think that lung qi deficiency,Lung missed the action of Management and Regulation in COPD is the main pathogenesis of inhibiting the K-ATP channel induced pulmonary vasoconstriction.VISCERAI manifestation theory guided this study,we choose COPD rat model of lung qi deficiency,regulate the K-ATP channel,intervent COPD pulmonary vasoconstriction,Reduct the pulmonary artery hypertension, clear the theory connotation and guiding role about〝Lung Governing Management and Regulation〞on COPD control,elucidate the relationship of pulmonary vasoconstriction and K-ATP channel during COPD reconstruction of Lung Governing Management and Regulation, Reveal the channel and targets of traditional Chinese medicine interventing COPD pulmonary vasoconstriction,innovate and enrich the visceral manifestation theory.