典型污染源四溴双酚A及其降解转化产物的环境暴露特征与健康风险

四溴双酚A（TBBPA）是目前世界上使用量最大的溴系阻燃剂，其环境健康风险一直备受关注。本项目针对电子废弃物回收拆解以及电子产品消费使用等典型TBBPA污染源，开展以TBBPA的环境界面过程、降解转化机理、毒性效应以及人群暴露风险为主要内容的研究。定量分析不同环境介质中TBBPA及其降解转化产物的污染负荷，通过多介质环境实验模拟，阐释TBBPA的环境界面过程与降解转化机理。采用不同模式生物的暴露实验，筛选TBBPA暴露生物标志物，揭示TBBPA及其降解转化产物毒性效应与作用机制，获得安全阈值。本研究将识别不同暴露场景下人群暴露特征，对其经口、经呼吸和皮肤接触等多种途径的摄入量参数进行深入细致的厘定，实现暴露剂量的精细化核算，综合表征典型污染源TBBPA及其降解转化产物的人群暴露健康风险。研究成果可为我国TBBPA阻燃剂生产、使用、管理和环境风险控制提供基础数据和重要科学依据。

Tetrabromobisphenol A (TBBPA), as the highest global production volume of all brominated flame retardant (BFR), has been of great concern for its environmental and human health risk. This proposal are aimed at exploring interfacial processes of TBBPA, potential degradation and conversion mechanisms of TBBPA, and evaluating human health risks of TBBPA in two typical TBBPA sources. The pollution loads of TBBPA and its degradation and transformation products will be quantified. TBBPA interfacial processes and its degradation and transformation mechanism will be explicated based on multimedia environment simulation. The different model organisms will be used to screen biomarkers of TBBPA exposure, explore the toxic effect and mechanism of TBBPA, and determine the safety threshold. Human exposure characteristics under different exposure scenarios will be identified and the intake parameters of oral, inhalation and dermal contact will be determined. Combined with the toxicity parameters and exposure doses determined by this project, human health risks via TBBPA and its degradation and transformation products exposure will be precisely characterized. Results of this project will provide scientific basis for the production and application of TBBPA flame retardant environmental risk control in our country.