Royal Jelly Alleviates Cognitive Deficits and β-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis
Royal Jelly Alleviates Cognitive Deficits and β-Amyloid Accumulation in APP/PS1 Mouse Model Via Activation of the cAMP/PKA/CREB/BDNF Pathway and Inhibition of Neuronal Apoptosis
复制标题
蜂王浆通过激活 cAMP/PKA/CREB/BDNF 通路和抑制神经元凋亡来减轻 APP/PS1 小鼠模型中的认知缺陷和 β-淀粉样蛋白积累
DOI：
10.3389/fnagi.2018.00428
复制
发表时间：
2019-01
影响因子：
4.8
通讯作者：
Fuliang Hu
中科院分区：
文献类型：
--
作者：
Mengmeng You;Yongming Pan;Yichen Liu;Fuliang Hu;Yuqi Wu;Juanjuan Si;Kai Wang;Fuliang Hu
阿尔茨海默病（Alzheimer's disease，AD）的临床特征是进行性认知功能减退，病理特征是β淀粉样蛋白（amyloid-β，Aβ）在脑内的蓄积。皇家浆（RJ）是蜜蜂下咽腺和下颌腺的分泌物，以前已被证明具有抗衰老和神经调节活性。在本研究中，我们发现RJ治疗3个月显著改善了APP/PS 1小鼠在Morris水迷宫（MWM）试验和跳台被动回避试验中的行为缺陷。我们的数据还表明，RJ显着减少APP/PS1小鼠的淀粉样斑块病理。此外，RJ通过抑制氧化应激来减轻c-Jun N末端激酶（JNK）磷酸化诱导的神经元凋亡。RJ治疗后APP/PS1小鼠海马cAMP、p-PKA、p-CREB和BDNF水平显著升高，提示RJ改善APP/PS1小鼠认知功能减退可能与cAMP/PKA/CREB/BDNF通路有关。总的来说，这些结果为使用RJ作为针对AD病理的功能性食物提供了科学依据。
Alzheimer's disease (AD) is characterized clinically by progressive cognitive decline and pathologically by the accumulation of amyloid-β (Aβ) in the brain. Royal jelly (RJ), a secretion of honeybee hypopharyngeal and mandibular glands, has previously been shown to have anti-aging and neuromodulatory activities. In this study, we discovered that 3 months of RJ treatment substantially ameliorated behavioral deficits of APP/PS1 mice in the Morris Water Maze (MWM) test and step-down passive avoidance test. Our data also showed that RJ significantly diminished amyloid plaque pathology in APP/PS1 mice. Furthermore, RJ alleviated c-Jun N-terminal kinase (JNK) phosphorylation-induced neuronal apoptosis by suppressing oxidative stress. Importantly, hippocampal cyclic adenosine monophosphate (cAMP), p-PKA, p-CREB and BDNF levels were significantly increased in the APP/PS1 mice after RJ treatment, indicating that the cAMP/PKA/CREB/BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline. Collectively, these results provide a scientific basis for using RJ as a functional food for targeting AD pathology.
登录
查看更多内容
影响因子：
1
作者：
Zamani Z;Reisi P;Alaei H;Pilehvarian AA
通讯作者：
Pilehvarian AA
影响因子：
4.8
作者：
Pan Y;Xu J;Chen C;Chen F;Jin P;Zhu K;Hu CW;You M;Chen M;Hu F
通讯作者：
Hu F
影响因子：
16.2
作者：
Putcha, GV;Le, SY;Johnson, EM
通讯作者：
Johnson, EM
影响因子：
5.6
作者：
Chen SD;Wu CL;Hwang WC;Yang DI
通讯作者：
Yang DI
DOI：
10.3233/jad-170512
发表时间：
2018
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Reddy PH;Manczak M;Yin X;Grady MC;Mitchell A;Tonk S;Kuruva CS;Bhatti JS;Kandimalla R;Vijayan M;Kumar S;Wang R;Pradeepkiran JA;Ogunmokun G;Thamarai K;Quesada K;Boles A;Reddy AP
通讯作者：
Reddy AP