TDCS guided using fMRI significantly accelerates learning to identify concealed objects.
TDCS guided using fMRI significantly accelerates learning to identify concealed objects.
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DOI：
10.1016/j.neuroimage.2010.11.036
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发表时间：
2012-01-02
期刊：
影响因子：
5.7
通讯作者：
Wassermann EM
中科院分区：
文献类型：
--
作者：
Clark VP;Coffman BA;Mayer AR;Weisend MP;Lane TD;Calhoun VD;Raybourn EM;Garcia CM;Wassermann EM
在复杂的环境中准确识别模糊和隐藏的物体是人类进化过程中生存所需的重要技能，并且今天需要许多形式的专业知识。在这里，我们使用经颅直流电刺激（tDCS）引导使用神经影像学，以提高学习率在一个新的，最低限度的指导发现学习范例。96名受试者识别出隐藏在现实世界训练中使用的自然虚拟环境中的威胁相关物体。在不同学习阶段收集的功能磁共振成像数据发现了各种各样的大脑网络，其中两个网络集中在右下额叶和右顶叶皮层。在一系列单盲、随机研究中，在这些区域进行阳极2.0 mA tDCS 30分钟，与0.1 mA tDCS相比，学习和性能显著改善。这种性能差异在延迟一小时后增加到两倍。电流强度对学习的剂量-反应效应也被发现。总之，这些脑成像和刺激研究表明，右额叶和顶叶皮层参与了在自然环境中识别隐藏物体的学习。此外，他们认为，在这些区域应用阳极tDCS可以大大增加学习，导致对学习的最大影响之一。这里开发的方法可能有助于减少在各种环境中获得专业知识所需的时间。
The accurate identification of obscured and concealed objects in complex environments was an important skill required for survival during human evolution, and is required today for many forms of expertise. Here we used transcranial direct current stimulation (tDCS) guided using neuroimaging to increase learning rate in a novel, minimally guided discovery-learning paradigm. Ninety-six subjects identified threat-related objects concealed in naturalistic virtual surroundings used in real-world training. A variety of brain networks were found using fMRI data collected at different stages of learning, with two of these networks focused in right inferior frontal and right parietal cortex. Anodal 2.0 mA tDCS performed for 30 minutes over these regions in a series of single-blind, randomized studies resulted in significant improvements in learning and performance compared with 0.1 mA tDCS. This difference in performance increased to a factor of two after a one-hour delay. A dose-response effect of current strength on learning was also found. Taken together, these brain imaging and stimulation studies suggest that right frontal and parietal cortex are involved in learning to identify concealed objects in naturalistic surroundings. Furthermore, they suggest that the application of anodal tDCS over these regions can greatly increase learning, resulting in one of the largest effects on learning yet reported. The methods developed here may be useful to decrease the time required to attain expertise in a variety of settings.
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DOI：
10.1007/bf03392173
发表时间：
2009-03-01
期刊：
BEHAVIOR ANALYST
影响因子：
--
作者：
Dymond, Simon;Roche, Bryan
通讯作者：
Roche, Bryan
影响因子：
56.9
作者：
Buschman, Timothy J.;Miller, Earl K.
通讯作者：
Miller, Earl K.
影响因子：
4.8
作者：
Burge, John;Lane, Terran;Clark, Vincent P.
通讯作者：
Clark, Vincent P.
影响因子：
64.8
作者：
Dolan, RJ;Fink, GR;Friston, KJ
通讯作者：
Friston, KJ
影响因子：
5.7
作者：
Clark, VP;Keil, K;Haxby, JV
通讯作者：
Haxby, JV