Biodegradable Polymeric Nanoparticles-Based Vaccine Adjuvants for Lymph Nodes Targeting.
Biodegradable Polymeric Nanoparticles-Based Vaccine Adjuvants for Lymph Nodes Targeting.
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DOI：
10.3390/vaccines4040034
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发表时间：
2016-10-12
期刊：
影响因子：
7.8
通讯作者：
Verrier B
中科院分区：
文献类型：
--
作者：
Gutjahr A;Phelip C;Coolen AL;Monge C;Boisgard AS;Paul S;Verrier B
疫苗已经成功地根除了许多疾病。然而，一些传染病（如艾滋病毒、沙眼衣原体或炭疽杆菌）继续蔓延，因为没有疫苗来预防它们。克服这一问题的一种方法是开发新的佐剂制剂，其能够诱导适当的免疫应答而不牺牲安全性。淋巴结是抗原呈递细胞引发淋巴细胞和随后的适应性免疫应答的位点，并且是疫苗制剂的有希望的靶点。在这篇综述中，我们描述了不同聚合物基（例如，聚乳酸-共-乙醇酸、聚乳酸.）颗粒佐剂作为创新系统，能够共同递送免疫增强剂和抗原。我们指出这些纳米颗粒如何增强抗原的递送，以及它们的物理化学性质如何改变它们被抗原呈递细胞的摄取和它们向淋巴结的迁移。我们描述了为什么聚合物纳米颗粒增加了进入淋巴结的持久性并促进了成熟的免疫反应。我们还强调纳米递送如何引导对特定抗原的反应，并允许诱导细胞毒性免疫反应，这对于对抗细胞内病原体或癌症至关重要。最后，我们强调了基于聚合物的疫苗和免疫增强剂之间的关联的兴趣，这可以通过将其引导到适当的隔室并降低其毒性来增强分子的作用。
Vaccines have successfully eradicated a large number of diseases. However, some infectious diseases (such as HIV, Chlamydia trachomatis or Bacillus anthracis) keep spreading since there is no vaccine to prevent them. One way to overcome this issue is the development of new adjuvant formulations which are able to induce the appropriate immune response without sacrificing safety. Lymph nodes are the site of lymphocyte priming by antigen-presenting cells and subsequent adaptive immune response, and are a promising target for vaccine formulations. In this review, we describe the properties of different polymer-based (e.g., poly lactic-co-glycolic acid, poly lactic acid …) particulate adjuvants as innovative systems, capable of co-delivering immunopotentiators and antigens. We point out how these nanoparticles enhance the delivery of antigens, and how their physicochemical properties modify their uptake by antigen-presenting cells and their migration into lymph nodes. We describe why polymeric nanoparticles increase the persistence into lymph nodes and promote a mature immune response. We also emphasize how nanodelivery directs the response to a specific antigen and allows the induction of a cytotoxic immune response, essential for the fight against intracellular pathogens or cancer. Finally, we highlight the interest of the association between polymer-based vaccines and immunopotentiators, which can potentiate the effect of the molecule by directing it to the appropriate compartment and reducing its toxicity.
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影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
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通讯作者：
Keler T