Strategies for the Integration of Cough and Swallow to Maintain Airway Protection in Humans.
Strategies for the Integration of Cough and Swallow to Maintain Airway Protection in Humans.
复制标题
咳嗽和吞咽相结合以维持人类气道保护的策略。
作者：
Huff A;Reed MD;Smith BK;Brown EH Jr;Ovechkin AV;Pitts T
呼吸道保护行为，如咳嗽和吞咽，在许多患有神经系统疾病的人群中恶化。虽然这些行为的协调已经在动物模型中进行了研究，但尚未在人类中进行过测试。我们使用了一种新的方案，改编自猫的先前工作，在7名健康男性（26 ± 6岁）中独立评估咳嗽和吞咽及其协调策略。颏下复合体和外斜肌复合体的表面肌电图，肺功能测定和胸腹壁运动学，用于评估吞咽，咳嗽和呼吸的时间以及这些行为期间的肺容量。与猫不同，咳嗽-吞咽阶段偏好存在显著变异性，但存在发生吞咽的目标肺体积范围。这些结果深入了解了猫和人类模型在与咳嗽和吞咽行为协调相关的气道保护策略方面的差异，从而更好地理解了吞咽困难和吞咽困难。
Airway protective behaviors, like cough and swallow, deteriorate in many populations suffering from neurologic disorders. While coordination of these behaviors has been investigated in an animal model, it has not been tested in humans. We used a novel protocol, adapted from previous work in the cat, to assess cough and swallow independently and their coordination strategies in seven healthy males (26 ± 6 years). Surface electromyograms of the submental complex and external oblique complex, spirometry and thoracic and abdominal wall kinematics, were used to evaluate the timing of swallow, cough, and breathing as well as lung volume during these behaviors. Unlike the cat, there was significant variability in the cough-swallow phase preference, however there was a targeted lung volume range in which swallow occurred. These results give insight into the differences between the cat and human models in airway protective strategies related to the coordination of cough and swallow behaviors, allowing for better understanding of dystussia and dysphagia.
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DOI：
10.1016/0034-5687(75)90019-5
发表时间：
1975-01-01
期刊：
RESPIRATION PHYSIOLOGY
影响因子：
--
作者：
DANGELO, E;AGOSTONI, E
通讯作者：
AGOSTONI, E
影响因子：
9.6
作者：
Pitts, Teresa;Troche, Michelle;Sapienza, Christine
通讯作者：
Sapienza, Christine
影响因子：
3.3
作者：
ASKANAZI, J;SILVERBERG, PA;KINNEY, JM
通讯作者：
KINNEY, JM
影响因子：
2.6
作者：
Hiss, SG;Treole, K;Stuart, A
通讯作者：
Stuart, A
影响因子：
5.5
作者：
Adrian, ED
通讯作者：
Adrian, ED